The Rim101 pathway mediates adaptation to external alkalization and altered lipid asymmetry: hypothesis describing the detection of distinct stresses by the Rim21 sensor protein
The Rim101 pathway mediates adaptation to external alkalization and altered lipid asymmetry: hypothesis describing the detection of distinct stresses by the Rim21 sensor protein
复制标题
Rim101 途径介导对外部碱化的适应和改变脂质不对称性：描述 Rim21 传感器蛋白检测不同应激的假设
DOI：
10.1007/s00294-020-01129-0
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发表时间：
2020
期刊：
影响因子：
2.5
通讯作者：
Kamura T
中科院分区：
文献类型：
--
作者：
Obara K;Kamura T
酵母细胞通过激活 Rim101 碱响应途径来适应碱性条件。 Rim21 充当 Rim101 通路中的传感器并检测细胞外碱化。有趣的是，Rim21 还被质膜脂质不对称性改变所激活。在本研究中，我们简要总结了 Rim101 通路的激活机制和信号转导级联，并提出了关于 Rim21 如何检测不同信号（特别是外部碱化）和改变的脂质不对称性的假设。我们发现外部碱化可以抑制质膜两个小叶之间磷脂的跨双层运动，这可能导致质膜脂质不对称性的紊乱。因此，我们认为 Rim21 至少部分通过脂质不对称的改变来感知外部改变。了解这种激活机制可以极大地促进针对真菌感染的药物开发。
Yeast cells adapt to alkaline conditions by activating the Rim101 alkali-responsive pathway. Rim21 acts as a sensor in the Rim101 pathway and detects extracellular alkalization. Interestingly, Rim21 is also known to be activated by alterations involving the lipid asymmetry of the plasma membrane. In this study, we briefly summarize the mechanism of activation and the signal transduction cascade of the Rim101 pathway and propose a hypothesis on how Rim21 is able to detect distinct signals, particularly external alkalization, and altered lipid asymmetry. We found that external alkalization can suppress transbilayer movements of phospholipids between the two leaflets of the plasma membrane, which may lead to the disturbance of the lipid asymmetry of the plasma membrane. Therefore, we propose that external alteration is at least partly sensed by Rim21 through alterations in lipid asymmetry. Understanding this activation mechanism could greatly contribute to drug development against fungal infections.