Vascular proliferation is a prognostic factor in breast cancer
Vascular proliferation is a prognostic factor in breast cancer
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DOI：
10.1007/s10549-011-1785-7
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发表时间：
2012-06-01
影响因子：
3.8
通讯作者：
Akslen, Lars A.
中科院分区：
文献类型：
--
作者：
Arnes, Jarle B.;Stefansson, Ingunn M.;Akslen, Lars A.
血管生成对于恶性肿瘤的生长和扩散很重要，目前正在评估针对乳腺癌和其他肿瘤的抗血管生成治疗。尽管微血管密度是肿瘤相关血管生成最常用的基于组织的标志物，但它具有显着的局限性，并且尚未被证明可以作为选择患者进行治疗的预测因素。我们想探讨血管内皮细胞增殖在乳腺癌中的意义。我们通过双重免疫组织化学染色检查了乳腺癌的微血管增殖，使用泛内皮标记因子 VIII 结合 Ki-67 表达的内皮细胞增殖，在三个独立的乳腺癌系列中，包括随访期间总共 499 名患者和 141 个事件。使用常见的关联统计检验以及患者生存的单变量和多变量回归分析。通过对活跃增殖的内皮血管进行计数，我们发现微血管增殖是乳腺癌疾病进展的重要预测因子，尤其是在高级别和 ER 阴性肿瘤中。我们的研究结果表明，这种活跃的肿瘤血管生成的新标志物可能对患者管理有价值，并且应该在选择抗血管生成治疗的患者的背景下进行进一步研究。
Angiogenesis is important for the growth and spread of malignant tumors, and anti-angiogenesis treatment is currently being evaluated for breast cancer and other tumors. Although microvessel density is the most commonly used tissue-based marker of tumor associated angiogenesis, it has significant limitations and has not proven effective as a predictive factor in selecting patients for treatment. We here wanted to explore the significance of vascular endothelial cell proliferation in breast carcinoma. We examined microvessel proliferation in breast cancer by dual immunohistochemical staining, using the pan-endothelial marker Factor-VIII combined with proliferation of endothelial cells by Ki-67 expression, in three independent series of breast cancer, including a total of 499 patients and 141 events during follow-up. Common statistical tests of associations as well as univariate and multivariate regression analysis of patient survival were used. By counting vessels with actively proliferating endothelium, we show that microvascular proliferation is a significant predictor of disease progression in breast cancer, especially among high-grade and ER-negative tumors. Our findings indicate that this novel marker of active tumor angiogenesis might be of value in patient management and should be further studied in the context of patient selection for anti-angiogenesis treatment.