Anticholinergic drugs and oral health-related quality of life in patients with schizophrenia: a pilot study
Anticholinergic drugs and oral health-related quality of life in patients with schizophrenia: a pilot study
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DOI：
10.1515/tnsci-2020-0003
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发表时间：
2020-01-01
影响因子：
2.1
通讯作者：
Denis, Frederic
中科院分区：
文献类型：
--
作者：
Chapuis, Justine;Siu-Paredes, Francesca;Denis, Frederic
目的：本研究的目的是在法国精神分裂症患者(PWS)的样本人群中，探讨抗胆碱能负荷对口腔健康相关生活质量(OHrQOL)的影响。方法：在2014年3月至2016年1月期间进行了一项先导性研究。PWS是从法国Cote d‘Or省的一个人口中招募的。使用龋齿、缺失或充填牙齿指数(DMFT)、口干症指数(XI)和全球口腔健康评估指数(GOHAI)为OHrQOL调查牙齿状况。用抗胆碱能浸润量表(AIS)记录抗胆碱能浸渍评分。结果：共抽取62人作为研究对象。DMFT评分16.5+/-8.7，XI评分22.9+/-7.8，GOHAI评分43.0+/-8.8，AIS评分3.1+/-2.8。总共给我们样本的人开了169种药物，观察到114种不同的抗胆碱能药物。研究中使用最多的抗胆碱能药物(51.40%)具有较低的抗心肌梗死效力(根据AIS评分为1分)。多元线性回归模型显示，DMFT评分、XI评分和抗胆碱能评分越高，OHrQOL评分越低。结论：这项初步研究强调了抗胆碱能负荷对PWS患者OHrQOL的潜在作用。应进行一项具有有效的OHrQOL特异量表和标准的抗胆碱能负荷量表的研究，以阐明抗胆碱能药物对PWS OHrQOL的作用。
Objective: The aim of this study was to explore, in a sample population of people with schizophrenia (PWS), the role of the anticholinergic burden on the perception of oral health-related quality of life (OHrQoL) in France. Methods: A pilot study was performed between March 2014 and January 2016. PWS were recruited from a population in Cote d'Or department in France. Dental status was investigated using the Decayed, Missing, or Filled Teeth (DMFT) index, the Xerostomia Index (XI), and the Global Oral Health Assessment Index (GOHAI) for OHrQoL. The anticholinergic impregnation score was recorded using the anticholinergic impregnation scale (AIS). Results: A sample of 62 people was selected. The DMFT score was 16.5 +/- 8.7, the XI score was 22.9 +/- 7.8, the GOHAI score was 43.0 +/- 8.8, and the AIS score was 3.1 +/- 2.8. In total, 169 drugs were prescribed to the people of our sample, and 114 different anticholinergic drugs were observed. The most frequently used anticholinergic drugs (51.40%), in the study had a low antimuscarinic potency (1 point according to AIS scale). The multiple linear regression model showed that the OHrQoL scores were significantly lower when the DMFT scores, XI score, and anticholinergic scores were high. Conclusions: This pilot study highlighted the potential role of the anticholinergic burden on the OHrQoL of PWS. A study with a validated specific scale for the OHrQoL and a standard anticholinergic burden scale should be conducted to clarify the role of anticholinergic drugs on the OHrQoL for PWS.