Prostate cancer gene therapy: outcome of basic research and clinical trials.
Prostate cancer gene therapy: outcome of basic research and clinical trials.
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前列腺癌基因治疗：基础研究和临床试验的成果。
DOI：
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发表时间：
1999
期刊：
影响因子：
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通讯作者：
H. Kumon
中科院分区：
文献类型：
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作者：
Y. Nasu;B. Djavan;M. Marberger;H. Kumon
随着基因工程、肿瘤生物学和免疫学的进步，基因治疗已被认为是一种有前途的治疗癌症的新选择，包括前列腺癌。目前正在进行的几项前列腺癌基因治疗的临床试验正在使用治疗基因，包括自杀基因、免疫调节基因、肿瘤抑制基因和抗癌基因。尽管前列腺癌基因治疗作为一种临床替代方案仍处于早期阶段，需要若干技术突破，但从临床试验中获得的信息表明前列腺癌基因治疗的全部潜力。基础研究和基因治疗技术的不断进步将为前列腺癌基因治疗在未来的广泛应用奠定基础。本文就前列腺癌基因治疗的一般概念及研究进展作一综述。
With the advances in genetic engineering, tumor biology, and immunology, gene therapy has been recognized as a promising new treatment option for cancer, including prostate cancer. Several clinical trials of prostate cancer gene therapy currently underway are using therapeutic genes, including suicide genes, immunomodulatory genes, tumor suppressor genes, and antioncogenes. Although gene therapy for prostate cancer as a clinical alternative is still at an early stage that requires several technological breakthroughs, information obtained from clinical trials indicates the full potential of prostate cancer gene therapy. Concordant progress in basic research and gene therapy technology will ready prostate cancer gene therapy for widescale use in the future. In this report, the general concept and current progress in prostate cancer gene therapy are summarized.