MOLECULAR THEORY OF SWEET TASTE
MOLECULAR THEORY OF SWEET TASTE
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DOI：
10.1002/jps.2600610910
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发表时间：
1972-01-01
影响因子：
3.8
通讯作者：
KIER, LB
中科院分区：
文献类型：
--
作者：
KIER, LB
对几个立体选择性的甜味氨基酸分子的研究，预测了第三个结构特征的存在和大致位置，相对于目前假定的葡萄糖团中的A-H/B特征。对几个不相关的甜味分子的研究支持了这一葡萄糖团假说。一系列取代的硝基苯胺的极化率参数与甜度水平之间的关系导致了这样的假设，即这第三个结合部位可能参与了具有适当受体特征的分散键。
A study of several stereoselectively sweet amino acid molecules has led to a prediction of the presence and approximate location of a third structural feature, relative to the currently postulated A—H/B features in the glucophore. An examination of several unrelated sweet molecules supports this glucophore hypothesis. A relationship between a polarizability parameter and sweetness level in a series of substituted nitroanilines leads to the hypothesis that this third binding site may be involved in dispersion bonding with an appropriate receptor feature.