Improved sensitivity and specificity for resting state and task fMRI with multiband multi-echo EPI compared to multi-echo EPI at 7 T
Improved sensitivity and specificity for resting state and task fMRI with multiband multi-echo EPI compared to multi-echo EPI at 7 T
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DOI：
10.1016/j.neuroimage.2015.06.089
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发表时间：
2015-10-01
期刊：
影响因子：
5.7
通讯作者：
Norris, David G.
中科院分区：
文献类型：
--
作者：
Boyacioglu, Rasim;Schulz, Jenni;Norris, David G.
实现了多带多回波(MBME)序列，并与匹配的标准多回波(ME)序列进行了比较，以研究7T时静息状态和任务fMRI的灵敏度和空间特异度的潜在改善。获得ME是有吸引力的，因为粗体灵敏度受T2*变化的影响较小，而且可以区分粗体和非粗体信号分量。MBME进一步降低了TR值，从而增加了降低生理噪声的可能性。在本研究中，我们使用FSL-FIX清理ME和MBME的静息状态和任务fMRI数据(均为3.5 mm各向同性)。经过噪声校正后，静止态网络的检测性能得到了改善，观察到了更多的非伪影独立分量。对于MBME数据，发现了任务数据的其他激活集群(提高了灵敏度)，而现有集群对于休息状态变得更加局部化(提高了空间专用性)。结果表明，在高场强下，MBME优于ME。(C)2015 Elsevier Inc.保留所有权利。
A multiband multi-echo (MBME) sequence is implemented and compared to a matched standard multi-echo (ME) protocol to investigate the potential improvement in sensitivity and spatial specificity at 7 T for resting state and task fMRI. ME acquisition is attractive because BOLD sensitivity is less affected by variation in T2*, and because of the potential for separating BOLD and non-BOLD signal components. MBME further reduces TR thus increasing the potential reduction in physiological noise. In this study we used FSL-FIX to clean ME and MBME resting state and task fMRI data (both 3.5 mm isotropic). After noise correction, the detection of resting state networks improves with more non-artifactual independent components being observed. Additional activation clusters for task data are discovered for MBME data (increased sensitivity) whereas existing clusters become more localized for resting state (improved spatial specificity). The results obtained indicate that MBME is superior to ME at high field strengths. (C) 2015 Elsevier Inc. All rights reserved.