musculin:: a murine basic helix-loop-helix transcription factor gene expressed in embryonic skeletal muscle
musculin:: a murine basic helix-loop-helix transcription factor gene expressed in embryonic skeletal muscle
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DOI：
10.1016/s0925-4773(98)00122-1
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发表时间：
1998-08-01
影响因子：
2.6
通讯作者：
Begley, CG
中科院分区：
文献类型：
--
作者：
Robb, L;Hartley, L;Begley, CG
我们描述了musclin的胚胎表达，一个新的小鼠成员的bHLH家族的转录因子。Musculin蛋白与人ABF-1密切相关。其在活化的B细胞中表达，以及在鳃成肌细胞中表达的心外膜蛋白/荚膜蛋白/Pod-1。内脏和泌尿生殖中胚层和心外膜。原位杂交显示，胚胎中的肌蛋白表达主要限于胚胎骨骼肌谱系。虽然所有的骨骼肌都表达该基因，但每块肌肉中只有一部分肌细胞呈阳性，表明胎儿肌肉中存在分子异质性。(C)1998爱思唯尔科学爱尔兰有限公司保留所有权利。
We describe the embryonic expression of musclin, a new murine member of the bHLH family of transcription factors. Musculin protein is closely related to human ABF-1. which is expressed in activated B cells, and to epicardin/capsulin/Pod-1, which is expressed in branchial myoblasts. visceral and urogenital mesoderm and epicardium. In situ hyhridisation revealed musculin expression in embryos was largely restricted to the embryonic skeletal muscle lineage. While all skeletal muscles expressed the gene, only a subset of myocytes within each muscle were positive, indicating molecular heterogeneity within fetal muscle. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.