Effect of atrial natriuretic factor on the plasma aldosterone response to potassium infusion in rats--in vivo study.
Effect of atrial natriuretic factor on the plasma aldosterone response to potassium infusion in rats--in vivo study.
复制标题
心房钠尿因子对大鼠血浆醛固酮对钾输注反应的影响——体内研究。
DOI：
10.1016/0024-3205(86)90654-5
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发表时间：
1986
期刊：
影响因子：
6.1
通讯作者：
Mulrow,PJ
中科院分区：
文献类型：
--
作者：
Takagi,M;Franco-Saenz,R;Mulrow,PJ
先前的体外研究表明，心房钠尿因子可抑制肾上腺细胞悬液中由AII、ACTH和钾刺激的醛固酮的分泌。本研究调查了 atriopeptin II 对清醒、不受约束的大鼠体内钾输注后血浆醛固酮反应的影响。输注氯化钾溶液使血浆醛固酮水平从 20.4 ± 3.7 增加至 168.4 ± 27.3 ng/dl。同时给予atriopeptin II可减少血浆醛固酮水平的增加（（16.0±2.1至63.3±10.4ng/dl）。两组之间血浆肾素活性、皮质酮或血清钾水平无显着差异。这些结果表明atriopeptin II可能在醛固酮分泌的调节中发挥重要作用。
Previous in vitro studies have shown that atrial natriuretic factor inhibits the secretion of aldosterone stimulated by AII, ACTH, and potassium in adrenal cell suspensions. The present study investigated the effects of atriopeptin II on the plasma aldosterone response to a potassium infusion in conscious unrestrained rats in vivo. The infusion of potassium chloride solution increased plasma aldosterone level from 20.4 ± 3.7 to 168.4 ± 27.3 ng/dl. The simultaneous administration of atriopeptin II reduced the increase in plasma aldosterone level ((16.0 ± 2.1 to 63.3 ± 10.4 ng/dl). There was no significant difference in the plasma renin activity, corticosterone, or serum potassium levels between the two groups. These results suggest that atriopeptin II may be important in the regulation of aldosterone secretion.