Bacterial scaffolds assemble novel higher-order complexes to reengineer eukaryotic cell processes.
Bacterial scaffolds assemble novel higher-order complexes to reengineer eukaryotic cell processes.
复制标题
细菌支架组装新型高阶复合物来重新设计真核细胞过程。
DOI：
10.1126/scisignal.2002252
复制
发表时间：
2011
影响因子：
7.3
通讯作者：
Leong,JohnM
中科院分区：
文献类型：
--
作者：
Lesser,CammieF;Leong,JohnM
许多微生物病原体使用专门的分泌系统将称为效应子的蛋白质直接注入真核宿主细胞中。这些效应器通常通过模仿宿主细胞蛋白的活性来直接靶向各种真核信号传导途径和细胞过程。致病性大肠杆菌和鼠伤寒沙门氏菌的效应子也可以充当分子支架，不仅招募而且直接调节多种真核蛋白的活性和定位。通过组装和定位不同的信号通路，细菌可以重新设计宿主细胞过程，以产生以前在真核细胞中未观察到的新过程。
Many microbial pathogens use specialized secretion systems to inject proteins referred to as effectors directly into eukaryotic host cells. These effectors directly target various eukaryotic signaling pathways and cellular processes, often by mimicking the activity of host cell proteins. Effectors of pathogenicEscherichia coliandSalmonella typhimuriumcan also act as molecular scaffolds that not only recruit but also directly regulate the activity and localization of multiple eukaryotic proteins. By assembling and localizing disparate signaling pathways, the bacteria can reengineer host cell processes to generate novel processes not previously observed in eukaryotic cells.