Difluoromethylation Reactions of Ethyl Pyruvate with the TDAE - A MildApproach to the Synthesis of 3,3-Difluoro-2-hydroxy-2-methyl-4-oxo-butyric Ethyl Esters Derivatives
Difluoromethylation Reactions of Ethyl Pyruvate with the TDAE - A MildApproach to the Synthesis of 3,3-Difluoro-2-hydroxy-2-methyl-4-oxo-butyric Ethyl Esters Derivatives
复制标题
丙酮酸乙酯与 TDAE 的二氟甲基化反应 - 合成 3,3-二氟-2-羟基-2-甲基-4-氧代-丁酸乙酯衍生物的温和方法
作者：
M. Médebielle;Katsuya Kato;W. Dolbier
在丙酮酸乙酯存在下，通过四（二甲氨基）乙烯（TDAE）介导的一系列 RCF 2 X（X = Cl 或Br）起始材料的还原，可以轻松以中等至良好的收率轻松获得新的 3,3-二氟-2-羟基-2-甲基-4-氧代-丁酸乙酯衍生物。
New 3,3-difluoro-2-hydroxy-2-methyl-4-oxo-butyric ethyl esters derivatives are easily obtained in moderate to good yields from the tetrakis(dimethylamino)ethylene (TDAE) mediated reduction of a series of RCF 2 X (X = Cl orBr) starting materials in the presence of ethyl pyruvate.