A highly sensitive fluorescent sensor for palladium based on the allylic oxidative insertion mechanism
A highly sensitive fluorescent sensor for palladium based on the allylic oxidative insertion mechanism
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DOI：
10.1021/ja073910q
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发表时间：
2007-10-17
影响因子：
15
通讯作者：
Koide, Kazunori
中科院分区：
文献类型：
--
作者：
Song, Fengling;Garner, Amanda L.;Koide, Kazunori
钯催化剂是有机合成中的强力试剂，但经过净化后的反应产物中仍常含有有害钯。因此，钯的检测是精细化学品和活性药物成分生产中的一个重要过程。我们开发了一种高灵敏度的荧光传感器，能够用肉眼定量检测1 ng的钯。使用这种方法，我们能够选择性地检测阿司匹林片中的钯污染（1mg阿司匹林中含有10ppm的钯，在实验室中混合进行这项研究），以前暴露于钯的烧瓶表面，以及含有钯的岩石。
Although palladium catalysts are powerful reagents in organic synthesis, hazardous palladium is often found in reaction products even after purifications. Thus, the detection of palladium is an important process in the production of fine chemicals and active pharmaceutical ingredients. We have developed a highly sensitive fluorescent sensor that is capable of detecting 1 ng of palladium quantitatively with the naked eye. Using this method, we were able to selectively detect palladium contamination in aspirin tablets (10 ppm Pd in 1 mg aspirin; mixed in the laboratory for this study), on the surface of flasks previously exposed to palladium, and in rocks containing palladium.