Copper complexes stimulate hemopoiesis and lymphopoiesis.
Copper complexes stimulate hemopoiesis and lymphopoiesis.
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铜络合物刺激造血和淋巴细胞生成。
DOI：
10.1007/978-1-4613-0537-8_18
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发表时间：
1989
影响因子：
--
通讯作者：
Sorenson,JR
中科院分区：
文献类型：
--
作者：
Soderberg,LS;Barnett,JB;Sorenson,JR
铜（II）2（3,5-二异丙基水杨酸盐）4[Cu(II)2(3,5- dips)4]是一种合成的铜配合物，具有多种作用，包括辐射恢复、抗炎和加速伤口愈合活性。皮下注射80μmol/kg Cu (II)2(3,5 - dips)4后，C57BL/6小鼠脾脏明显增大。脾肿大持续至少3周，并伴有脾内骨髓增生增加。骨髓细胞结构和骨髓形成无明显变化。Cu(II)2(3,5- dips)4对脾细胞对有丝分裂或抗原刺激的反应能力只有轻微的影响。Cu(II)2(3,5- dips)4确实刺激了淋巴细胞生成，因为它加速了暴露于8gy全身照射后免疫反应性的恢复。Cu(II)2(3,5- dips)4对未照射小鼠的脾和骨髓中铜的含量在给药24小时后无显著升高，在给药7天后有短暂性降低。
Copper(II)2(3,5-diisopropylsalicylate)4[Cu(II)2(3, 5-DIPS)4] is a synthetic copper complex with a variety of effects, including radiation recovery, anti-inflammatory, and accelerated wound healing activities. When C57BL/6 mice were injected subcutaneously with 80μmol/kg Cu (II)2(3, 5-DIPS)4their spleens significantly enlarged. This splenomegally lasted for at least 3 weeks and was accompanied by increased myelopoiesis in the spleen. Bone marrow had no significant change in cellularity or myelopoiesis. The treatment with Cu(II)2(3,5-DIPS)4had only minor effects on the ability of spleen cells to respond to mitogenic or antigenic stimulation. Cu(II)2(3,5-DIPS)4did stimulate lymphopoiesis, since it accelerated the recovery of immune reactivity following exposure to 8 Gy whole body irradiation. Copper levels in the spleens and bone marrow of unirradiated mice treated with Cu(II)2(3,5-DIPS)4were not significantly elevated 24 hr after treatment and copper levels were transiently reduced 7 days after treatment.