Evaluation of Hepatic Focal Lesions Using Diffusion-Weighted MR Imaging: Comparison of Apparent Diffusion Coefficient and Intravoxel Incoherent Motion-Derived Parameters
Evaluation of Hepatic Focal Lesions Using Diffusion-Weighted MR Imaging: Comparison of Apparent Diffusion Coefficient and Intravoxel Incoherent Motion-Derived Parameters
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DOI：
10.1002/jmri.24158
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发表时间：
2014-02-01
影响因子：
4.4
通讯作者：
Choi, Byung Ihn
中科院分区：
文献类型：
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作者：
Yoon, Jeong Hee;Lee, Jeong Min;Choi, Byung Ihn
目的对比表观扩散系数（ADC(total)），探讨采用多重b值的体素内非相干运动(IVIM)-弥散加权成像（DWI）获得的参数是否能改善常见局灶性肝脏病变（FLLs）的表征。材料和方法美国机构审查委员会批准了这项回顾性研究，并放弃了知情同意。总共有142例169例fll患者在3.0T时接受了肝脏磁共振成像（MRI），包括IVIM-DWI和多个b因子。计算每个病变的ADC（total）和ivim - dwi衍生参数，包括真扩散（D-t）、假扩散（D-p）和灌注分数(f)，并使用专用软件进行比较。结果恶性肿瘤的d (t)和ADC（总）(0.950.21,1.14 +/- 0.24,(x10（-3) mm(2)/sec）明显低于良性肿瘤(1.61 +/- 0.34,1.72 +/- 0.37,（x10(-3) mm(2)/sec)）。在良恶性鉴别诊断中，D-t （Az值：0.971）优于ADC(total) (Az值：0.933)（P < 0.05）
PurposeTo determine whether parameters obtained from intravoxel incoherent motion (IVIM)-diffusion-weighted imaging (DWI) using multiple b-values can improve characterization of common focal liver lesions (FLLs), compared with the apparent diffusion coefficient (ADC(total)).Materials and MethodsOur Institutional Review Board approved this retrospective study and informed consent was waived. In all, 142 patients with 169 FLLs underwent liver magnetic resonance imaging (MRI) including IVIM-DWI with multiple b factors at 3.0T. ADC(total) and IVIM-DWI-derived parameters including true diffusion (D-t), pseudodiffusion (D-p), and perfusion fraction (f) were calculated for each lesion and compared using dedicated software.ResultsD(t) and ADC(total) were significantly lower in malignancies (0.950.21, 1.14 +/- 0.24, (x10(-3) mm(2)/sec)) than in benign FLLs (1.61 +/- 0.34, 1.72 +/- 0.37, (x10(-3) mm(2)/sec)). In the differential diagnosis of malignancies from benign lesions, D-t (Az value: 0.971) showed better diagnostic performance than ADC(total) (Az: 0.933) (P