Effects of 6-hydroxydopamine-induced norepinephrine depletion on cerebellar development.
Effects of 6-hydroxydopamine-induced norepinephrine depletion on cerebellar development.
复制标题
6-羟基多巴胺诱导的去甲肾上腺素耗竭对小脑发育的影响。
DOI：
10.1159/000112695
复制
发表时间：
1982
影响因子：
2.9
通讯作者：
K. Lovell
中科院分区：
文献类型：
--
作者：
K. Lovell
为了研究去甲肾上腺素（NE）对神经元发育的可能影响，在（1）正常小鼠小脑和（2）新生儿甲基偶氮甲醇乙酸酯（MAM）给药产生的小脑模型系统中表征了新生儿NE耗竭对出生后发育细胞群的影响。通过新生儿6-羟基多巴胺（6-OHDA）注射实现NE含量的降低。在MAM处理组中，6-OHDA在外胚层（EGL）重建中未产生显著变化。在其他组中，6-OHDA处理产生了蚓部面积的减少、叶状结构的改变和EGL发育时间表的变化。这些结果支持NE在调节小脑神经元发育中的作用。
In order to investigate the possible influence of norepinephrine (NE) on neuronal development, the effects of neonatal NE depletion on postnatally developing cell populations were characterized in (1) the normal mouse cerebellum, and (2) a cerebellar model system with delayed germinal cell development produced by neonatal methylazoxymethanol acetate (MAM) administration. Reduction in NE content was achieved by neonatal 6-hydroxydopamine (6-OHDA) injections. In the MAM-treated groups, 6-OHDA did not produce significant changes in external germinal layer (EGL) reconstitution. In the other groups, 6-OHDA treatment produced a reduction in the vermis area, alterations in foliation, and changes in the schedule of EGL development. These results support a role for NE in regulation of neuronal development in the cerebellum.