Prenatal nicotine exposure and the programming of metabolic and cardiovascular disorders
Prenatal nicotine exposure and the programming of metabolic and cardiovascular disorders
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DOI：
10.1016/j.mce.2009.02.026
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发表时间：
2009-05-25
影响因子：
4.1
通讯作者：
Hueppi, Petra S.
中科院分区：
文献类型：
--
作者：
Somm, Emmanuel;Schwitzgebel, Valerie M.;Hueppi, Petra S.
目前，越来越多的兴趣集中在“代谢综合征”的起源上，代谢综合征是将肥胖、血脂异常、高血压和2型糖尿病联系在一起的几种代谢紊乱的集合。显然，遗传易感性和有害的生活方式，包括低体力活动和高热量营养，对代谢综合征的发生有影响。然而，最近的数据表明，代谢综合征也可能是“编程”在宫内生活的各种侮辱不断增长的胎儿。尼古丁是烟草中发现的主要兴奋剂和形成依赖性的生物碱，尽管有医学建议，但统计数据显示，20-30%的女性吸烟者在怀孕期间继续吸烟，约占所有怀孕人数的10%。因此，尼古丁是发育中的胎儿接触的最普遍的危险化学物质之一。目前的审查重点是最近的流行病学调查和实验动物研究提供的证据表明，产前和产后尼古丁暴露可能是一个促成因素，发生代谢紊乱以后的生活。(C)2009爱思唯尔爱尔兰有限公司保留所有权利。
Presently, a growing interest is focused on the origins of the "Metabolic Syndrome", a cluster of several metabolic disorders linking obesity, dyslipidemia, hypertension and type 2 diabetes mellitus. Clearly, genetic predisposition and deleterious lifestyle, including low physical activity and hypercaloric alimentation, have an influence on the occurrence of the Metabolic Syndrome. However, recent data suggest that the Metabolic Syndrome could also be "programmed" during intrauterine life by diverse insults to the growing foetus. Nicotine is the main stimulant and dependence-forming alkaloid found in tobacco, and despite medical advice, statistics show that 20-30% of female smokers continue the habit during gestation, representing around 10% of all pregnancies. In consequence, nicotine is one of the most universally dangerous chemicals to which developing foetuses are exposed. The present review focuses on recent epidemiological surveys and experimental animal studies that provide evidences indicating that pre- and postnatal nicotine exposure might be a contributing factor for the occurrence of metabolic disorders later in life. (C) 2009 Elsevier Ireland Ltd. All rights reserved.