FETAL GROWTH-RETARDATION DUE TO MATERNAL TOBACCO-SMOKE EXPOSURE IN THE RAT
FETAL GROWTH-RETARDATION DUE TO MATERNAL TOBACCO-SMOKE EXPOSURE IN THE RAT
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DOI：
10.1203/00006450-198402000-00002
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发表时间：
1984-01-01
影响因子：
3.6
通讯作者：
JAMES, LS
中科院分区：
文献类型：
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作者：
BASSI, JA;ROSSO, P;JAMES, LS
怀孕期间吸烟会导致后代的平均出生体重比不吸烟的母亲低200克。这种影响的发病机制仍然是未知的，也没有普遍同意的因果关系之间的母亲吸烟和随后的胎儿生长迟缓。在这里，使用P和I沃尔顿暴露机建立了大鼠妊娠期间母亲吸烟的模型。研究包括3组：对照组、配对喂养组和烟雾暴露组。从妊娠第5-20天开始，将暴露于烟雾的动物连续暴露于烟草烟雾中，周期为7 min，16次/天。在妊娠第21天，通过剖宫产取出所有组的胎仔，称重并解剖。称重胎脑、肝、肺和胎盘并分析核酸含量。与对照组相比，配对喂养组和烟雾暴露组的胎儿体重显著降低。与配对喂养组相比，烟雾暴露组动物的胎仔体重也显著降低。母亲暴露于烟雾中既不影响胎儿脑重量，也不影响核酸含量;胎儿肝脏和肺的重量和核酸含量显着下降。大鼠中与母体暴露于烟草烟雾相关的胎儿生长迟缓对应于不成比例的类型。母亲烟草烟雾暴露可诱导胎儿生长迟缓，而无胎盘生长迟缓。
Smoking during [human] pregnancy results in offspring with an average birth weight 200 g less than those of nonsmoking mothers. Pathogenesis of this effect is still unknown and there is no general agreement about the causal relationship between maternal smoking and subsequent fetal growth retardation. Here, a model of maternal smoking during pregnancy in the rat was established using the P and I Walton Exposure Machine. The study consisted of 3 groups: control, pair-fed and smoke-exposed. Smoke-exposed animals were exposed continuously to tobacco smoke for cycles of 7 min, 16 times/day from d [day] 5-20 of gestation. On d 21 of gestation, fetuses from all groups were removed by cesarean section, weighed and dissected. Fetal brain, liver, lungs, and placentas were weighed and analyzed for nucleic acid content. Fetal weight was significantly reduced in pair-fed and smoke-exposed groups compared with the control group. There was also a significant reduction in fetal body weight of the animals in the smoke-exposed group in comparison to those in the pair-fed group. Exposing the mother to smoke affected neither fetal brain weight nor nucleic acid content; fetal liver and lungs showed a significant decrease in weight and nucleic acid content. Fetal growth retardation associated with maternal exposure to tobacco smoke in the rat corresponds to a disproportionate type. Maternal tobacco smoke exposure induced fetal growth retardation without placental growth retardation.