Prostate cancer assessment using MR elastography of fresh prostatectomy specimens at 9.4 T
Prostate cancer assessment using MR elastography of fresh prostatectomy specimens at 9.4 T
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DOI：
10.1002/mrm.28127
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发表时间：
2019-12-10
影响因子：
3.3
通讯作者：
Klatt, Dieter
中科院分区：
文献类型：
--
作者：
Reiter, Rolf;Majumdar, Shreyan;Klatt, Dieter
目的：尽管多参数MRI在前列腺癌（PCa）的诊断中取得了成功，但仍存在观察者间变异性和特异性低等局限性。目前正在讨论几种MRI方法，其中包括MR弹性成像，作为补充传统多参数MRI的候选方法。本研究旨在探讨使用MR弹性成像检测新鲜离体人类前列腺切除术标本中的PCa。方法采用9.4T临床前扫描仪，对14例前列腺癌患者行根治性前列腺切除术后即刻行500Hz磁共振弹性成像检查。将样本分成12段，用于计算储能模量（G '，以千帕计）和病理学（Gleason评分）作为参考标准。计算敏感性、特异性和受试者工作特征曲线下面积以评估PCa检测。结果各节段的平均G '和SD分别为8.74 ± 5.26kPa、5.44 ± 4.40kPa和10.84 ± 4.65kPa。正常节段与癌节段之间差异有显著性意义，P
Purpose Despite its success in the assessment of prostate cancer (PCa), in vivo multiparametric MRI has limitations such as interobserver variability and low specificity. Several MRI methods, among them MR elastography, are currently being discussed as candidates for supplementing conventional multiparametric MRI. This study aims to investigate the detection of PCa in fresh ex vivo human prostatectomy specimens using MR elastography. Methods Fourteen fresh prostate specimens from men with clinically significant PCa without formalin fixation or prior radiation therapy were examined by MR elastography at 500 Hz immediately after radical prostatectomy in a 9.4T preclinical scanner. Specimens were divided into 12 segments for both calculation of storage modulus (G ' in kilopascals) and pathology (Gleason score) as reference standard. Sensitivity, specificity, and area under the receiver operating characteristic curve were calculated to assess PCa detection. Results The mean G ' and SD were as follows: all segments, 8.74 +/- 5.26 kPa; healthy segments, 5.44 +/- 4.40 kPa; and cancerous segments, 10.84 +/- 4.65 kPa. The difference between healthy and cancerous segments was significant with P