Sex ratios among children of lupus pregnancies.
Sex ratios among children of lupus pregnancies.
复制标题
狼疮妊娠儿童的性别比例。
DOI：
10.1002/art.37718
复制
发表时间：
2013
影响因子：
--
通讯作者：
Salmon,JaneE
中科院分区：
文献类型：
--
作者：
MichaelDLockshin;Cohn,Elisabeth;Aslam,Aanam;Buyon,JillP;Salmon,JaneE
A recent paper1 stated that maternal antibody to the N-methyl-D-aspartate receptor (NMDAR) causes death of female fetuses of BALB/c mice, leading to offspring male/female (m/f) ratios greater than the normal ratio of 1.0. Since about 40% of patients with systemic lupus erythematosus (SLE) have anti-NMDAR, if the mouse model is predictive, m/f ratios in human SLE pregnancies might exceed the United States normal ratio of 1.048.Our pregnancy studies offer an opportunity to test this prediction. PROMISSE (Predictors of Pregnancy Outcome: Biomarkers in Antiphospholipid Syndrome and Systemic Lupus Erythematosus) is a multicenter, prospective study of pregnancies of mothers with lupus; 2 the Research Registry for Neonatal Lupus (RRNL) is a registry of families in which the mother has anti-SSA/Ro and/or SSB/La antibodies and at least one child with neonatal lupus. RRNL includes both affected and unaffected children. 3
