Glioma invasion along white matter tracts: A dilemma for neurosurgeons
Glioma invasion along white matter tracts: A dilemma for neurosurgeons
复制标题
胶质瘤沿白质束侵袭：神经外科医生的困境
DOI：
10.1016/j.canlet.2021.11.020
复制
发表时间：
2022
期刊：
影响因子：
9.7
通讯作者：
Shi-cang Yu
中科院分区：
文献类型：
--
作者：
Jun Wang;Liang Yi;Qing-mei Kang;Ji Zhou;Tian-qing Chen;Jean-philippe Hugnot;Shi-cang Yu
沿白质束侵袭性生长是胶质瘤最突出的临床病理特征之一，也是胶质瘤患者手术治疗失败的重要原因。充分了解相关临床特征和机制，对于寻找新的治疗靶点，制定新的治疗方案和策略具有重要意义。本文就脑胶质瘤患者WM束侵袭的影像学和组织学特征进行综述，并对其可能的分子机制进行总结。在此基础上，我们进一步探讨胶质瘤分子分型、放疗及肿瘤治疗野（TTFields）与胶质瘤沿WM束侵袭的关系。
Invasive growth along white matter (WM) tracts is one of the most prominent clinicopathological features of glioma and is also an important reason for surgical treatment failure in glioma patients. A full understanding of relevant clinical features and mechanisms is of great significance for finding new therapeutic targets and developing new treatment regimens and strategies. Herein, we review the imaging and histological characteristics of glioma patients with WM tracts invasion and summarize the possible molecular mechanism. On this basis, we further discuss the correlation between glioma molecular typing, radiotherapy and tumor treating fields (TTFields) and the invasion of glioma along WM tracts.