The use of lipid-based nanocarriers for targeted pain therapies.
The use of lipid-based nanocarriers for targeted pain therapies.
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DOI：
10.3389/fphar.2013.00143
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发表时间：
2013-11-21
影响因子：
5.6
通讯作者：
Wu SY
中科院分区：
文献类型：
--
作者：
Hua S;Wu SY
止痛剂在靶部位的持续输送仍然是有效疼痛管理的关键问题。据报道，纳米载体的使用有助于将这些药物有效地输送到靶点，同时将全身毒性降至最低。这包括使用可生物降解的脂质体或聚合物载体。其中，脂质体由于其灵活的物理化学性质而成为一种有吸引力的给药系统，可以方便地进行操作，以满足不同的给药考虑。其良好的毒性特征和易于大规模生产也使其临床应用可行。本文将对脂质体作为药物载体的概念、体外特性以及体内行为进行综述。本文将介绍止痛剂脂质体靶向给药的最新进展及其对疼痛治疗领域的影响。
Sustained delivery of analgesic agents at target sites remains a critical issue for effective pain management. The use of nanocarriers has been reported to facilitate effective delivery of these agents to target sites while minimizing systemic toxicity. These include the use of biodegradable liposomal or polymeric carriers. Of these, liposomes present as an attractive delivery system due to their flexible physicochemical properties which allow easy manipulation in order to address different delivery considerations. Their favorable toxicity profiles and ease of large scale production also make their clinical use feasible. In this review, we will discuss the concept of using liposomes as a drug delivery carrier, their in vitro characteristics as well as in vivo behavior. Current advances in the targeted liposomal delivery of analgesic agents and their impacts on the field of pain management will be presented.
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影响因子：
5.7
作者：
Gambling, D;Hughes, T;Manvelian, G
通讯作者：
Manvelian, G
影响因子：
--
作者：
Metselaar, JM;Wauben, MHM;Storm, G
通讯作者：
Storm, G
影响因子：
6.8
作者：
Bendas, G
通讯作者：
Bendas, G
DOI：
10.1016/j.ijbiomac.2013.06.041
发表时间：
2013-10-01
影响因子：
8.2
作者：
Kumar, Manoj;Pandey, Ravi Shankar;Madan, Jitender
通讯作者：
Madan, Jitender
影响因子：
3.9
作者：
Gorfine, Stephen R.;Onel, Erol;Krivokapic, Zoran V.
通讯作者：
Krivokapic, Zoran V.