Abnormal metabolic network activity in REM sleep behavior disorder
Abnormal metabolic network activity in REM sleep behavior disorder
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DOI：
10.1212/wnl.0000000000000130
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发表时间：
2014-02-18
期刊：
影响因子：
9.9
通讯作者：
Montplaisir, Jacques
中科院分区：
文献类型：
--
作者：
Holtbernd, Florian;Gagnon, Jean-Francois;Montplaisir, Jacques
目的：确定特发性 REM 睡眠行为障碍 (RBD) 中帕金森病相关协方差模式 (PDRP) 表达是否异常增加，以及基线活动增加是否与后续表型转变的个体风险更大相关。 方法：在本队列研究中，我们招募了 2 组 RBD 受试者和对照受试者。第 1 组由 10 名 RBD 受试者（63.5±9.4 岁）和 10 名健康志愿者（62.7±8.6 岁）组成，他们接受了 F-18-氟脱氧葡萄糖 PET 静息态代谢脑成像。第 2 组由 17 名 RBD 受试者（68.9 +/- 4.8 岁）和 17 名健康志愿者（66.6 +/- 6.0 岁）组成，他们接受了半胱氨酸乙酯二聚体 SPECT 静息脑灌注成像。对成像结果不知情的研究人员对后一组进行了 4.6 +/- 2.5 年的临床随访。测量两个 RBD 组的 PDRP 表达，并与相应的对照值进行比较。结果：两组 RBD 受试者的 PDRP 表达均升高（队列 1：p < 0.04；队列 2：p < 0.005）。在17名长期随访的受试者中，8名被诊断患有帕金森病或路易体痴呆；其他人没有发生表型转变。对于患有 RBD 的个体受试者，使用基于 PDRP 表达和成像时受试者年龄的逻辑回归模型预测最终表型转变状态 (r(2) = 0.64，p < 0.0001)。结论：特发性 RBD 受试者的潜在网络异常与随后表型转变为进行性神经退行性综合征的可能性更大有关。
Objective:To determine whether the Parkinson disease-related covariance pattern (PDRP) expression is abnormally increased in idiopathic REM sleep behavior disorder (RBD) and whether increased baseline activity is associated with greater individual risk of subsequent phenoconversion.Methods:For this cohort study, we recruited 2 groups of RBD and control subjects. Cohort 1 comprised 10 subjects with RBD (63.5 9.4 years old) and 10 healthy volunteers (62.7 8.6 years old) who underwent resting-state metabolic brain imaging with F-18-fluorodeoxyglucose PET. Cohort 2 comprised 17 subjects with RBD (68.9 +/- 4.8 years old) and 17 healthy volunteers (66.6 +/- 6.0 years old) who underwent resting brain perfusion imaging with ethylcysteinate dimer SPECT. The latter group was followed clinically for 4.6 +/- 2.5 years by investigators blinded to the imaging results. PDRP expression was measured in both RBD groups and compared with corresponding control values.Results:PDRP expression was elevated in both groups of subjects with RBD (cohort 1: p < 0.04; cohort 2: p < 0.005). Of the 17 subjects with long-term follow-up, 8 were diagnosed with Parkinson disease or dementia with Lewy bodies; the others did not phenoconvert. For individual subjects with RBD, final phenoconversion status was predicted using a logistical regression model based on PDRP expression and subject age at the time of imaging (r(2) = 0.64, p < 0.0001).Conclusions:Latent network abnormalities in subjects with idiopathic RBD are associated with a greater likelihood of subsequent phenoconversion to a progressive neurodegenerative syndrome.