Long-term burden of higher body mass index from childhood on adult cardiometabolic biomarkers: A 30-year cohort study
Long-term burden of higher body mass index from childhood on adult cardiometabolic biomarkers: A 30-year cohort study
复制标题
儿童期较高体重指数对成人心脏代谢生物标志物的长期负担：一项为期 30 年的队列研究。
DOI：
10.1016/j.numecd.2020.09.009
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发表时间：
2021-02-12
影响因子：
3.9
通讯作者：
Mu, Jian-Jun
中科院分区：
文献类型：
--
作者：
Liao, Yue-Yuan;Chu, Chao;Mu, Jian-Jun
Background and aims: Data are limited regarding the association between long-term burden of higher body mass index (BMI) from childhood and cardiometabolic biomarkers.Methods and results: A total of 1553 individuals aged 6-15 years, who were examined 4 or more times for BMI since childhood and followed for 30 years were included in our analysis. Total area under the curve (AUCt) and incremental AUC (AUCi) were calculated as the long-term burden and trends of BMI. Cardiometabolic biomarkers including serum uric acid (SUA), fasting blood-glucose (FBG), and triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C) were obtained from venous blood samples. The results showed a positive association of BMI AUCt and AUCi with cardiometabolic biomarkers. After adjusting for demographic variables, the AUCt and AUCi of BMI were significantly associated with a higher level of SUA (beta = 3.71; 2.87), FBG (beta = 0.09; 0.09), and TG/HDL-C (beta = 0.14; 0.11). We performed further studies after dividing subjects into four groups according to AUCt and AUCi of BMI by quartiles. Compared with the lowest quartile group, the highest quartile group had significantly increased risk ratios of hyperuricemia (RR = 2.01; 1.74), type 2 diabetes mellitus (RR = 8.18; 3.96), and high-risk TG/HDL-C (RR = 4.05; 3.26).Conclusion: Our study identifies all subjects' BMI growth curve from childhood and indicates that the long-term burden of higher BMI significantly increases the cardiometabolic risk, and the impact of excessive body weight on cardiometabolic health originates in early life. We emphasize the importance of weight control from childhood for cardiometabolic health. (C) 2020 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V.
