Improvement of sleep apnea in patients with chronic renal failure who undergo nocturnal hemodialysis
Improvement of sleep apnea in patients with chronic renal failure who undergo nocturnal hemodialysis
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DOI：
10.1056/nejm200101113440204
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发表时间：
2001-01-11
影响因子：
158.5
通讯作者：
Pierratos, A
中科院分区：
文献类型：
--
作者：
Hanly, PJ;Pierratos, A
背景资料：睡眠呼吸暂停在慢性肾功能衰竭患者中很常见，常规血液透析或腹膜透析都不能改善。在夜间血液透析中，患者每周7个晚上在家中进行血液透析，同时睡觉。我们假设，夜间血液透析将纠正慢性肾功能衰竭患者的睡眠呼吸暂停，因为其更大的effectiveness. Methods：14例患者进行常规血液透析，每周三天，每天4小时进行夜间多导睡眠图。然后，患者在每周的六到七个晚上中的每个晚上进行八小时的夜间血液透析。6~15个月后，他们在进行夜间血液透析的一个晚上和不进行血液透析的另一个晚上再次进行多导睡眠图检查。患者接受夜间血液透析期间的平均（+/-SD）血清肌酐浓度显著低于接受常规血液透析期间（3.9 +/-1.1 vs. 12.8 +/-3.2毫克/分升[342 +/-101微摩尔/升vs. 1131 +/-287微摩尔/升]，P
Background: Sleep apnea is common in patients with chronic renal failure and is not improved by either conventional hemodialysis or peritoneal dialysis. With nocturnal hemodialysis, patients undergo hemodialysis seven nights per week at home, while sleeping. We hypothesized that nocturnal hemodialysis would correct sleep apnea in patients with chronic renal failure because of its greater effectiveness.Methods: Fourteen patients who were undergoing conventional hemodialysis for four hours on each of three days per week underwent overnight polysomnography. The patients were then switched to nocturnal hemodialysis for eight hours during each of six or seven nights a week. They underwent polysomnography again 6 to 15 months later on one night when they were undergoing nocturnal hemodialysis and on another night when they were not.Results: The mean (+/-SD) serum creatinine concentration was significantly lower during the period when the patients were undergoing nocturnal hemodialysis than during the period when they were undergoing conventional hemodialysis (3.9+/-1.1 vs. 12.8+/-3.2 mg per deciliter [342+/-101 vs. 1131+/-287 micromol per liter], P