Meta-analysis of cue-reactivity in addiction research
Meta-analysis of cue-reactivity in addiction research
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DOI：
10.1046/j.1360-0443.1999.9433273.x
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发表时间：
1999-03-01
期刊：
影响因子：
6
通讯作者：
Tiffany, ST
中科院分区：
文献类型：
--
作者：
Carter, BL;Tiffany, ST
目标。线索-反应程序将成瘾者暴露在各种与药物有关的刺激下，同时监测渴望的自我报告和生理反应。本综述试图确定线索-反应性研究中常见的反应的大小和总体模式，以及哪些基于学习的线索反应性模型最能得到研究结果的支持。设计。元分析技术被用来选择和评估41项线索反应性研究的结果，这些研究比较了酗酒者、吸烟者、可卡因成瘾者或海洛因成瘾者对与药物相关的刺激和中性刺激的反应。根据成瘾者的类型，分别计算效果大小，以自我报告渴望和生理反应(心率、汗腺活动和皮肤温度)。调查结果。在所有上瘾人群中，对渴望的影响大小为+0.92。酗酒者的渴求效应大小(+0.53)明显小于其他成瘾者组(+1.18至+1.29)。生理反应的效应大小相对较小。所有吸毒者组的总体效应大小是，当吸毒者接受与药物相关的刺激时，心率(+0.26)和汗腺活动(+0.40)增加，皮肤温度降低(-0.24)。结论。线索-反应性范式可以产生稳定的显著效应，因此在研究成瘾现象方面有许多潜在的应用。这些发现对基于条件的模型和线索-反应现象的含义进行了讨论。
Aims. The cue-reactivity procedure exposes addicts to a variety of drug-related stimuli while self-report of craving and physiological responses are monitored. The present review sought to determine the magnitude and overall pattern of responses typically found in cue-reactivity research and which, if any, learning-based model of cue reactivity is best supported by the findings. Design. Meta-analytical techniques were used to select and evaluate results from 41 cue-reactivity studies that compared responses of alcoholics, cigarette smokers, cocaine addicts or heroin addicts to drug-related versus neutral stimuli. Effect sizes were calculated, separately by addict type, for self-report of craving and physiological responses (heart rate, sweat gland activity and skin temperature). Findings. Across all addict groups, the effect size for craving was + 0.92. Alcoholics had a significantly smaller craving effect size (+ 0.53) compared to other addict groups (+1.18 to + 1.29). Relatively smaller effect sizes were found for physiological responses. The general profile of effect sizes across all addict groups was increased heart rate (+ 0.26) and sweat gland activity (+ 0.40) and decreased skin temperature (- 0.24) when addicts were presented with drug-related stimuli. Conclusions. The cue-reactivity paradigm can produce a stable profile of significant effects and, therefore, has a number of potential applications for investigating addictive phenomena. The implications of these findings for conditioning-based models; of cue-reactivity phenomena are discussed.