GRADE guidelines: 2. Framing the question and deciding on important outcomes
GRADE guidelines: 2. Framing the question and deciding on important outcomes
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DOI：
10.1016/j.jclinepi.2010.09.012
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发表时间：
2011-04-01
影响因子：
7.2
通讯作者：
Schuenemann, Holger J.
中科院分区：
文献类型：
--
作者：
Guyatt, Gordon H.;Oxman, Andrew D.;Schuenemann, Holger J.
GRADE 需要对相关环境、人群、干预措施和比较器进行明确说明。它还要求详细说明所有重要结果，无论研究的证据是否可用。对于特定的管理问题，不同研究中的人群、干预措施和结果应该足够相似，这样相似程度的影响是合理的。指南制定者应在收集证据之前以及证据摘要完成后再次指定结果的相对重要性。在考虑替代结果的重要性时，作者应该评估替代结果对患者重要的结果的重要性，并随后降低结果间接性的证据质量。 (C) 2011 Elsevier Inc. 保留所有权利。
GRADE requires a clear specification of the relevant setting, population, intervention, and comparator. It also requires specification of all important outcomes whether evidence from research studies is, or is not, available. For a particular management question, the population, intervention, and outcome should be sufficiently similar across studies that a similar magnitude of effect is plausible. Guideline developers should specify the relative importance of the outcomes before gathering the evidence and again when evidence summaries are complete. In considering the importance of a surrogate outcome, authors should rate the importance of the patient-important outcome for which the surrogate is a substitute and subsequently rate down the quality of evidence for indirectness of outcome. (C) 2011 Elsevier Inc. All rights reserved.