Altered directional connectivity between emotion network and motor network in Parkinson's disease with depression.
Altered directional connectivity between emotion network and motor network in Parkinson's disease with depression.
复制标题
帕金森病抑郁症患者情绪网络和运动网络之间的方向连接发生改变
DOI：
10.1097/md.0000000000004222
复制
发表时间：
2016-07
期刊：
影响因子：
1.6
通讯作者：
Li K
中科院分区：
文献类型：
--
作者：
Liang P;Deshpande G;Zhao S;Liu J;Hu X;Li K
帕金森病（PD）患者常伴有抑郁，抑郁可加重PD的其他症状。本研究采用静息态功能磁共振成像（rs-fMRI）技术，对16例抑郁性帕金森病（DPD）患者、20例非抑郁性帕金森病（NDPD）患者、20例正常对照组和20例正常对照组进行了研究。对17例抑郁症患者和21例健康对照者进行结构MRI和rs-fMRI扫描。分析了静息状态下基于体素的形态测量学和方向性脑连接。以性别、年龄、受教育程度、结构性萎缩和/或HAMD、统一PD评定量表（Uniform PD Rating Scale，UPD RS）为协变量，采用方差分析（ANOVA）和双样本t检验对各组进行比较，与NC组相比，DPD组边缘系统中线区（包括背内侧前额叶皮质和楔前叶）和皮质下区（包括尾状核和小脑）的灰质（gray matter，GM）体积明显异常。相对于NC和MDD，DPD和NDPD均显示从双侧前颞叶和后眶额皮质到左侧下颞叶皮质的方向性连接显著增加。与NC、MDD和NDPD相比，DPD患者的定向连接改变主要发生在双侧前额叶和后眶额皮质到右侧基底节的通路上，在控制年龄、性别、结构性萎缩等因素后，DPD患者的情绪网络与运动网络在静息状态下存在定向连接改变。鉴于这些改变是DPD独有的，它可能提供一个潜在的差异生物标志物，用于区分DPD与NC，NDPD和MDD。
AbstractDepression is common in patients with Parkinson's disease (PD), which can make all the other symptoms of PD much worse. It is thus urgent to differentiate depressed PD (DPD) patients from non-depressed PD (NDPD).The purpose of the present study was to characterize alterations in directional brain connectivity unique to Parkinson's disease with depression, using resting state functional magnetic resonance imaging (rs-fMRI).Sixteen DPD patients, 20 NDPD patients, 17 patients with major depressive disorder (MDD) and 21 healthy control subjects (normal controls [NC]) underwent structural MRI and rs-fMRI scanning. Voxel-based morphometry and directional brain connectivity during resting-state were analyzed. Analysis of variance (ANOVA) and 2-sample t tests were used to compare each pair of groups, using sex, age, education level, structural atrophy, and/or HAMD, unified PD rating scale (UPDRS) as covariates.In contrast to NC, DPD showed significant gray matter (GM) volume abnormalities in some mid-line limbic regions including dorsomedial prefrontal cortex and precuneus, and sub-cortical regions including caudate and cerebellum. Relative to NC and MDD, both DPD and NDPD showed significantly increased directional connectivity from bilateral anterior insula and posterior orbitofrontal cortices to left inferior temporal cortex. As compared with NC, MDD and NDPD, alterations of directional connectivity in DPD were specifically observed in the pathway from bilateral anterior insula and posterior orbitofrontal cortices to right basal ganglia.Resting state directional connectivity alterations were observed between emotion network and motor network in DPD patients after controlling for age, sex, structural atrophy. Given that these alterations are unique to DPD, it may provide a potential differential biomarker for distinguishing DPD from NC, NDPD, and MDD.