The S1A protease family members CG10764 and CG4793 regulate cellular immunity in Drosophila.
The S1A protease family members CG10764 and CG4793 regulate cellular immunity in Drosophila.
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DOI：
10.17912/micropub.biology.000370
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发表时间：
2021-02-22
影响因子：
--
通讯作者：
Mortimer NT
中科院分区：
文献类型：
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作者：
Kr P;Lee J;Mortimer NT
在自然界中，果蝇幼虫被寄生蜂感染，并对这种感染产生细胞免疫反应。几个保守的信号通路已经被牵连在协调这种反应，但我们的理解这些途径的整合和调节是不完整的。S1A丝氨酸蛋白酶家族的成员先前已被链接到免疫功能，我们的研究结果表明两个S1A家族成员，CG10764和CG4793在寄生虫感染的细胞免疫反应中的作用。
In nature, Drosophila melanogaster larvae are infected by parasitoid wasps and mount a cellular immune response to this infection. Several conserved signaling pathways have been implicated in coordinating this response, however our understanding of the integration and regulation of these pathways is incomplete. Members of the S1A serine protease family have been previously linked to immune functions, and our findings suggest roles for two S1A family members, CG10764 and CG4793 in the cellular immune response to parasitoid infection.