Regional oxygenation and radiotherapy: a study of the degradation of infused hydrogen peroxide. I. Infusate mixing.
Regional oxygenation and radiotherapy: a study of the degradation of infused hydrogen peroxide. I. Infusate mixing.
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区域氧合和放射治疗：注入过氧化氢降解的研究。
DOI：
10.1080/09553007114550551
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发表时间：
1971
期刊：
影响因子：
--
通讯作者：
J. I. MacNaughton
中科院分区：
文献类型：
--
作者：
J. I. MacNaughton
将同时注入过氧化物和放射治疗后的治疗效果归因于氧的作用是假设注入的过氧化物分解得非常快。文献给出了过氧化氢分解速率的不同值，一个支持氧效应，另一个辅音与“过氧化效应”。用模拟体内流动条件的模型系统进行了体外实验，研究了输液在流动流体中的混合情况。即使经过一秒钟，混合也不完美。讨论了不完全混合对分解速率的影响。通过硬膜外插管输注产生很少或没有湍流来帮助混合。观察到两种活性化学物质（过氧化物和高锰酸盐）可以在管内以流形式共存。血液过氧化氢酶和注入过氧化物之间也可能有类似的行为。过氧化氢的分解注入流动的血液直接检查。
SummaryTo ascribe the therapeutic benefits following simultaneous peroxide infusion and radiotherapy to the oxygen effect is to assume that the infused peroxide breaks down very rapidly. The literature gives disparate values for the rate of decomposition of peroxide, one supporting the oxygen effect, the other consonant with a ‘peroxide effect’.In vitro experiments with model systems simulating in vivo flow conditions have been used to examine the mixing of infusate in a stream of flowing fluid. Mixing has been shown to be imperfect even after one second has elapsed. The effect of imperfect mixing on the decomposition rate has been discussed.Infusion through an epidural cannula produces little or no turbulence to assist mixing.It was observed that two reactive chemical species (peroxide and permanganate) can coexist in stream form within a tube. Similar behaviour between blood catalase and infused peroxide may also be possible.The decomposition of peroxide infused into flowing blood is examined directly i...