Hormonal prevention of breast cancer: Mimicking the protective effect of pregnancy
Hormonal prevention of breast cancer: Mimicking the protective effect of pregnancy
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DOI：
10.1073/pnas.96.5.2520
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发表时间：
1999-03-02
影响因子：
11.1
通讯作者：
Nandi, S
中科院分区：
文献类型：
--
作者：
Guzman, RC;Yang, J;Nandi, S
早期足月妊娠是预防女性乳腺癌最有效的自然保护措施。用化学致癌物处理的大鼠同样受到先前怀孕的保护，免于乳腺癌的发生。乳腺的增殖和分化不能解释这种现象，正如奋乃静（一种有效的促有丝分裂和分化剂）相对无效所示。在这里，我们表明，短期治疗未经生育的大鼠与妊娠水平的雌二醇17 β和孕酮具有很高的疗效，保护他们从化学致癌物诱导的乳腺癌。由于在足月妊娠期间乳腺暴露于最高生理浓度的雌二醇和孕酮，因此这些升高的激素水平可能会诱导乳腺癌的保护。因此，它似乎有可能模仿保护作用的怀孕对乳腺癌的未经生育的大鼠短期特定的激素干预。
Full term pregnancy early in life is the most effective natural protection against breast cancer in women. Rats treated with chemical carcinogen are similarly protected by a previous pregnancy from mammary carcinogenesis. Proliferation and differentiation of the mammary gland does not explain this phenomenon, as shown by the relative ineffectiveness of perphenazine, a potent mitogenic and differentiating agent. Here, we show that short term treatment of nulliparous rats with pregnancy levels of estradiol 17 beta and progesterone has high efficacy in protecting them from chemical carcinogen induced mammary canters. Because the mammary gland is exposed to the highest physiological concentrations of estradiol and progesterone during full term pregnancy, it is these elevated levels of hormones that likely induce protection from mammary cancer. Thus, it appears possible to mimic the protective effects of pregnancy against breast cancer in nulliparous rats by short term specific hormonal intervention.