HLA-allele matched unrelated donors compared to HLA-matched sibling donors: role of cell source and disease risk category.
HLA-allele matched unrelated donors compared to HLA-matched sibling donors: role of cell source and disease risk category.
复制标题
DOI：
10.1016/j.bbmt.2010.03.024
复制
发表时间：
2010-10
影响因子：
4.3
通讯作者：
Petersdorf, Effie
中科院分区：
文献类型：
--
作者：
Woolfrey, Ann;Lee, Stephanie J.;Gooley, Ted A.;Malkki, Mari;Martin, Paul J.;Pagel, John M.;Hansen, John A.;Petersdorf, Effie
为了确定当供者是完全匹配的非亲缘供者（基于10/10 HLA等位基因，MUD）与HLA相同的同胞时，同种异体移植的风险是否不同，我们对1448例高危或晚期恶性血液病患者进行了回顾性分析，这些患者在清髓性预处理后接受了T细胞完全移植。MSD和10/10 MUD的接受者在生存率、无病生存率和非复发死亡率方面没有发现统计学显著差异，对于高危疾病患者或给予骨髓作为移植物来源的患者。然而，对于接受外周血移植的中危疾病患者，我们观察到与MSD队列相比，10/10 MUD组的非复发死亡率较高，总生存率较低。MUD组的移植物抗宿主病（GvHD）高于MSD组。这些结果表明，如果患者有高风险疾病和MSD是不可用的，HLA等位基因匹配的MUD的选择可能会提供类似的总体和无病生存，因此缺乏MSD本身不应该排除这样的患者接受移植。然而，对于中危疾病患者，与MSD相比，来自10/10 MUD的外周血移植与较低的存活率相关。
In order to determine whether the risks of allogeneic transplantation are different when the donor is a fully matched unrelated donor (based on 10/10 HLA alleles, MUD) compared to an HLA-identical sibling, we performed a retrospective analysis of 1448 patients with high-risk or advanced hematologic malignancies given T-replete grafts after myeloablative conditioning. No statistically significant differences were found between recipients of MSD and 10/10 MUD in survival, disease-free survival and non-relapse mortality for patients with high-risk disease or those given bone marrow as a graft source. However, for patients with intermediate-risk disease receiving peripheral blood grafts, we observed higher non-relapse mortality and lower overall survival in the 10/10 MUD group compared to the MSD cohort. Graft-versus-host disease (GvHD) was higher in the MUD group compared to the MSD group. These results suggest that if a patient has high-risk disease and a MSD is not available, selection of an HLA-allele-matched MUD may provide similar overall and disease-free survival, and therefore lack of a MSD in and of itself should not preclude such a patient from undergoing transplantation. However, for patients with intermediate-risk disease, transplantation with peripheral blood from a 10/10 MUD is associated with lower survival than a MSD.
登录
查看更多内容
影响因子：
3.7
作者：
KAPLAN, EL;MEIER, P
通讯作者：
MEIER, P
影响因子：
2.3
作者：
Stanulla, Martin;Cario, Gunnar;Schrappe, Martin
通讯作者：
Schrappe, Martin
影响因子：
20.3
作者：
Ringden, Olle;Pavletic, Steven Z.;Arora, Mukta
通讯作者：
Arora, Mukta
影响因子：
20.3
作者：
Petersdorf, EW;Anasetti, C;Hansen, JA
通讯作者：
Hansen, JA
影响因子：
20.3
作者：
Lee, Stephanie J.;Klein, John;Anasetti, Claudio
通讯作者：
Anasetti, Claudio