Carbohydrate balance predicts weight and fat gain in adults
Carbohydrate balance predicts weight and fat gain in adults
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DOI：
10.1093/ajcn/83.4.803
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发表时间：
2006-04-01
影响因子：
7.1
通讯作者：
Hill, JO
中科院分区：
文献类型：
--
作者：
Eckel, RH;Hernandez, TL;Hill, JO
背景资料：肥胖的预防和治疗是一个公共卫生的挑战。目的：我们调查了膳食组成、胰岛素敏感性（S-1）和能量平衡油预测身体组成变化的影响。设计：在一项随机交叉设计研究中，39名正常体重（n = 23），超重（n = 8），和肥胖（n = 8）的男性和女性（年龄25-36岁）在第一年中分别遵循15-d等热量高脂肪（HF; 50%脂肪）和高碳水化合物[HC; 55%碳水化合物（CHO）]饮食以及4-6周的洗脱期。在每次治疗期间，在受试者不活动时通过使用间接量热法在第15天测量能量平衡，并且通过使用正葡萄糖钳夹研究测量S-1 wits（40 mU（.）m（-2 .）min（-1））油第16天。然后每年测量体重和身体成分，持续4年。结果：HC饮食组的CHO平衡（第15天）与S-1（第16天）高度显著相关（r = 0.55，P <0.001），HC饮食组的CHO平衡（第15天）与S-1（第16天）显著相关（r = 0.55，P < 0.001）。在HC饮食中，具有较高正CHO平衡（第15天）的受试者随时间增加的脂肪量（P < 0.001）、体脂百分比（P = 0.006）和体重（P = 0.024）较少。当调整S-1，CHO平衡仍然是脂肪量（P = 0.021）和体脂百分比（P = 0.025）的变化的一个显着的预测因素。结论：油HC饮食，受试者谁有较高的积极CHO平衡的第15天，而他们是不活跃的获得较少的脂肪量在4年期间，预测效果独立于S-1。就像啮齿类动物一样。扩大糖原库的能力可能会减少能量摄入，防止脂肪和体重增加。
Background: The prevention and treatment of obesity is a public health challenge.Objective: We investigated the effects of dietary composition, insulin sensitivity (S-1), and energy balance oil predicted changes in body composition.Design: In a randomized crossover design study, 39 normal-weight (n = 23), overweight (it = 8), and obese (n = 8) men and women (aged 25-36 y) each followed a 15-d isocaloric high-fat (HF; 50% fat) and high-carbohydrate [HC; 55% carbohydrate (CHO)] diet with a 4-6-wk washout period during the first year. During each treatment, energy balance was Measured while the subjects were inactive by using indirect calorimetry oil day 15, and S-1 wits measured by using a euglycemic clamp study (40 mU (.) m(-2 .) min(-1)) oil day 16. Weight and body composition were then measured annually for 4 y. The outcomes for fat mass, percentage body fat, and weight were measured by using a linear 2-stage mixed model.Results: CHO balance (day 15) and S-1 (day 16) oil the HC diet were highly and significantly correlated (r = 0.55, P < 0.001). Oil the HC diet, the subjects who had a higher positive CHO balance (day 15) gained less fat mass (P < 0.001), percentage body fat (P = 0.006) and weight (P = 0.024) over time. When adjusted for S-1, CHO balance remained a significant predictor of changes in fat mass (P = 0.021) and percentage body fat (P = 0.025).Conclusions: Oil a HC diet, the Subjects who had a higher positive CHO balance on day 15 while they were inactive gained less fat mass during 4 y, a predictive effect independent of S-1. As suggested in rodents. the capacity to expand the glycogen pool might reduce energy intake and protect against fat and weight gain.