Antifungal Secondary Metabolites Isolated from Mangrove Rhizosphere Soil-Derived Penicillium Fungi
Antifungal Secondary Metabolites Isolated from Mangrove Rhizosphere Soil-Derived Penicillium Fungi
复制标题
从红树林根际土壤来源的青霉真菌中分离出抗真菌次生代谢物
DOI：
10.1007/s11802-020-4360-1
复制
发表时间：
2020-06-01
影响因子：
1.6
通讯作者：
Chen, Min
中科院分区：
文献类型：
--
作者：
Shen, Nanxing;Liang, Zhaoyang;Chen, Min
Fungi isolated from mangrove rhizosphere soil of the South China Sea were investigated for the production of potential antifungal metabolites. With 28 fungal isolates, the strains Penicillium javanicum HK1-23 and P. janthinellum HK1-6 showed significant antifungal activities. A bioassay-guided investigation of the two fungal strains led to the isolation of two secondary metabolites, brefeldin A and penicillic acid, with high yields of 143 and 423 mg L −1 , respectively. Penicillic acid showed potent antifungal activities toward Rhizoctonia solani and R. cerealis , with 67.5% and 76% growth inhibition, respectively, at 50 μg mL −1 . Brefeldin A showed strong activity toward R. cerealis , with 56.4% growth inhibition at 50 μg mL −1 .
