Anabolic steroid abuse and dependence.
Anabolic steroid abuse and dependence.
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DOI：
10.1007/s11920-002-0086-6
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发表时间：
2002-10-01
影响因子：
6.7
通讯作者：
Brower, Kirk J
中科院分区：
文献类型：
--
作者：
Brower, Kirk J
合成代谢雄激素类固醇（AAS）主要用于治疗雄激素缺乏综合征，最近还用于治疗分解代谢状态，例如与艾滋病相关的消瘦。所审查的文献中没有证据表明 AAS 滥用或依赖是由 AAS 的治疗用途引起的。相反，据报道，举重运动员和健美运动员中有 165 例对 AAS 依赖，作为举重训练方案的一部分，他们长期服用超生理剂量，通常包括注射和口服 AAS 以及其他滥用药物的组合。提出了一种新模型，其中 AAS 的“肌肉活性”和精神活性作用均有助于 AAS 依赖性的发展。审查 AAS 的不良后果，并通过病史、身体、精神状态检查和实验室测试进行评估。当 AAS 使用障碍患者与其他物质使用障碍患者进行比较时，相似点和差异都变得显而易见，并对治疗产生影响。
Anabolic-androgenic steroids (AAS) are mainly used to treat androgen deficiency syndromes and, more recently, catabolic states such as AIDS-associated wasting. There is no evidence in the reviewed literature that AAS abuse or dependence develops from the therapeutic use of AAS. Conversely, 165 instances of AAS dependence have been reported among weightlifters and bodybuilders who, as part of their weight training regimens, chronically administered supraphysiologic doses, often including combinations of injected and oral AAS as well as other drugs of abuse. A new model is proposed in which both the "myoactive" and psychoactive effects of AAS contribute to the development of AAS dependence. The adverse consequences of AAS are reviewed, as well as their assessment by means of a history and physical, mental status examination, and laboratory testing. When patients with AAS use disorders are compared with patients with other substance use disorders, both similarities and differences become apparent and have implications for treatment.