Evolution of the diverse antifreeze proteins
Evolution of the diverse antifreeze proteins
复制标题
DOI：
10.1016/s0959-437x(98)80042-7
复制
发表时间：
1998-12-01
影响因子：
4
通讯作者：
Cheng, CHC
中科院分区：
文献类型：
--
作者：
Cheng, CHC
不同类型的冰生长抑制抗冻蛋白最初是在鱼类中发现的，现在已经从昆虫和植物中分离出来，而且这个范围还在不断扩大。它们的结构极其多样化；它们如何实现相同的功能是深入研究的课题。几个成员的进化前体已经被鉴定出来——功能明显不相关的不同蛋白质。来自这些分子的结构和分子进化研究的信息的杂交提供了一个论坛，在这个论坛中可以连贯地解决选择、基因谱系、适应性进化和新功能的发明等问题。
Different types of ice-growth-inhibiting antifreeze proteins, first recognized in fish, have now been isolated from insects and plants, and the list continues to expand. Their structures are amazingly diverse; how they attain the same function are subjects of intense research. Evolutionary precursors of several members have been identified - divergent proteins of apparently unrelated function. The hybridization of information from structural and molecular evolution studies of these molecules provides a forum in which issues of selection, gene genealogy, adaptive evolution, and invention of a novel function can be coherently addressed.