Prognostic value of SUVmax measurements obtained by FDG-PET in patients with non-small cell lung cancer receiving chemotherapy
Prognostic value of SUVmax measurements obtained by FDG-PET in patients with non-small cell lung cancer receiving chemotherapy
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DOI：
10.1016/j.lungcan.2010.04.004
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发表时间：
2011-01-01
期刊：
影响因子：
5.3
通讯作者：
Aizawa, Hisamichi
中科院分区：
文献类型：
--
作者：
Imamura, Yohei;Azuma, Koichi;Aizawa, Hisamichi
[F-18]氟脱氧葡萄糖(FDG)摄取已被证明与肿瘤增殖率有很好的相关性。在接受化疗的非小细胞肺癌(NSCLC)患者中，我们分析了FDG正电子发射断层扫描(FDG-PET)获得的最大标准化摄取值(SUVmax)与其他临床因素的关系，并检验SUVmax能否预测无进展生存期(PFS)和/或总生存期(OS)。这项回顾性研究涉及62名连续的非小细胞肺癌患者(男性35名，女性27名：中位年龄65岁)。所有患者在治疗前均接受FDG-PET检查。化疗加放疗(n=15)或不加放疗(n=47)作为一线治疗。生存曲线采用Kaplan-Meier法，亚组间生存差异采用对数列检验和Cox比例风险模型分析。SUVmax与性别(P=0.006)、组织学(P
[F-18]Fluorodeoxyglucose (FDG) uptake has been shown to correlate well with tumor proliferation rates. In patients with non-small cell lung cancer (NSCLC) receiving chemotherapy, we analyzed the relationships between the maximum standardized uptake value (SUVmax) obtained by FDG positron emission tomography (FDG-PET) and other clinical factors, and examined whether or not SUVmax could predict progression-free survival (PFS) and/or overall survival (OS). This retrospective study involved 62 consecutive NSCLC patients (35 male and 27 female: median age, 65 years). All patients underwent FDG-PET examination before treatment. As the first-line treatment, the patients received chemotherapy with (n=15) or without (n=47) radiotherapy. Survival curves were obtained by the Kaplan-Meier method, and differences in survival between subgroups were analyzed by the log-rank test and the Cox proportional hazards model. Significant correlations were observed between SUVmax and gender (P=0.006), histology (P