Microvascular Density of Rapidly Destructive Arthropathy of the Hip Joint
Microvascular Density of Rapidly Destructive Arthropathy of the Hip Joint
复制标题
髋关节快速破坏性关节病的微血管密度
DOI：
10.1177/230949900501300107
复制
发表时间：
2005
影响因子：
1.6
通讯作者：
A. Uchida
中科院分区：
文献类型：
--
作者：
T. Yamakawa;A. Sudo;M. Tanaka;A. Uchida
目的。评估股骨头的血管，并确定它与髋关节关节炎的破坏有何关系。关节炎髋关节的破坏性关节病的过程是多种多样的。一些髋关节骨性关节炎患者具有快速进行性破坏性改变，导致股骨头消失。方法。对6例诊断为快速破坏性关节病的股骨头和6例髋臼发育不良继发性骨关节炎患者的股骨头进行了分析，以揭示毛细血管和破骨细胞之间的关系。用von Willebrand因子免疫组织化学染色和Mayer‘s苏木素复染标记福尔马林固定、石蜡包埋的股骨头标本中的微血管和破骨细胞。计数免疫组织化学染色的微血管和破骨细胞的数量。结果。快速进展性关节炎髋关节骨面微血管密度较高。在快速进展性关节炎髋关节的骨表面也发现破骨细胞的数量增加。较高的微血管密度与广泛的骨质破坏和破骨细胞计数的增加相一致。结论。提示股骨头肉芽组织血管丰富可能与骨质破坏和关节破坏有关。
Purpose. To assess the vascularity of the femoral head and determine how it is related to the destruction of the arthritic hip joint. The process of destructive arthropathy in arthritic hip joints is variable. Some patients with osteoarthritis of the hip have rapidly progressive destructive changes resulting in the disappearance of the femoral head. Method. Six femoral heads from patients diagnosed with rapidly destructive arthropathy and 6 femoral heads from patients with secondary osteoarthritis caused by acetabular dysplasia were analysed to reveal the association between blood capillaries and osteoclasts. The von Willebrand Factor immunostaining and counterstaining with Mayer's haematoxylin were used to label the microvessels and osteoclasts in formalin-fixed, paraffin-embedded specimens of femoral heads. The numbers of immunostained microvessels and osteoclasts in selected regions were counted. Result. The microvascular density of the bone surfaces of rapidly progressive arthritic hips was hypervascular. Osteoclasts were also found in increased numbers on the bone surfaces of rapidly progressive arthritic hips. The higher microvascular density coincided with extensive bone destruction and with the increased osteoclast count. Conclusion. These findings suggested that hypervascularity of the granulation in the femoral head may be associated with bone and joint destruction.
影响因子：
158.5
作者：
WEIDNER, N;SEMPLE, JP;FOLKMAN, J
通讯作者：
FOLKMAN, J
DOI：
10.1210/jcem.81.5.8626854
发表时间：
1996-05
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
R. Devlin;H. Bone;G. David Roodman
通讯作者：
R. Devlin;H. Bone;G. David Roodman
破骨细胞组成型表达骨吸收调节因子：免疫组织化学和原位杂交研究。
DOI：
--
发表时间：
1997
期刊：
Laboratory investigation; a journal of technical methods and pathology.
影响因子：
--
作者：
O'Keefe,RJ;Teot,LA;Singh,D;Puzas,JE;Rosier,RN;Hicks,DG
通讯作者：
Hicks,DG