The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function
The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function
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DOI：
10.1016/s0022-510x(99)00210-5
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发表时间：
1999-10-31
影响因子：
4.4
通讯作者：
Nakanishi, A
中科院分区：
文献类型：
--
作者：
Cedarbaum, JM;Stambler, N;Nakanishi, A
ALS功能评定量表（ALSFRS）是一种有效的评定工具，用于监测肌萎缩侧索硬化症（ALS）患者的残疾进展。最初设计的ALSFRS的一个缺点是，与呼吸功能障碍相比，它给予肢体和球不成比例的重量。我们现在已经验证了ALSFRS的修订版，其中包含了对呼吸困难、矫形呼吸和呼吸支持需求的额外评估。修订后的ALSFRS （ALSFRS- r）保留了原始量表的特性，并表现出较强的内部一致性和结构效度。ALSFRS-R评分与疾病影响谱测量的生活质量显著相关，表明功能质量是ALS患者生活质量的重要决定因素。(C) 1999 Elsevier Science B.V.版权所有
The ALS Functional Rating Scale (ALSFRS) is a validated rating instrument for monitoring the progression of disability in patients with amyotrophic lateral sclerosis (ALS). One weakness of the ALSFRS as originally designed was that it granted disproportionate weighting to limb and bulbar, as compared to respiratory, dysfunction. We have now validated a revised version of the ALSFRS, which incorporates additional assessments of dyspnea, orthopnea, and the need for ventilatory support. The Revised ALSFRS (ALSFRS-R) retains the properties of the original scale and shows strong internal consistency and construct validity. ALSFRS-R scores correlate significantly with quality of life as measured by the Sickness Impact Profile, indicating that the quality of function is a strong determinant of quality of life in ALS. (C) 1999 Elsevier Science B.V. All rights reserved.