Lack of HIV-1 integrase inhibitor resistance among 392 antiretroviral-naive individuals in a tertiary care hospital in Beijing, China
Lack of HIV-1 integrase inhibitor resistance among 392 antiretroviral-naive individuals in a tertiary care hospital in Beijing, China
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DOI：
10.1097/qad.0000000000002282
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发表时间：
2019-10-01
期刊：
影响因子：
3.8
通讯作者：
Zhang, Tong
中科院分区：
文献类型：
--
作者：
Liu, Lifeng;Dai, Lili;Zhang, Tong
对整合酶链转移抑制剂（INSTIs）耐药的报道现在并不罕见。我们分析了急性和慢性HIV - 1感染期间未接受过抗逆转录病毒治疗个体血浆中的HIV int基因。未发现有主要INSTI突变的个体。首次检测到两名个体携带INSTI辅助突变E157Q/T97A。我们的研究结果强调有必要考虑在基线时检测INSTI耐药性，因为这类药物在临床常规中使用越来越多。
Reports of resistance to integrase strand transfer inhibitors (INSTIs) are now not uncommon. We analyzed the HIV int gene from plasma of antiretroviral-naive individuals during acute and chronic HIV-1 infection. No individual with major INSTI mutations was identified. Two individuals harbored INSTI accessory mutations E157Q/T97A were detected for the first time. Our results emphasize the need to consider testing for INSTI resistance at baseline as this class of drugs is increasingly used in clinical routine.