Sexual dimorphism in immunometabolism and autoimmunity: Impact on personalized medicine.
Sexual dimorphism in immunometabolism and autoimmunity: Impact on personalized medicine.
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DOI：
10.1016/j.autrev.2021.102775
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发表时间：
2021-04
影响因子：
13.6
通讯作者：
Liang Y
中科院分区：
文献类型：
--
作者：
Manuel RSJ;Liang Y
免疫细胞在代谢动态平衡中起着至关重要的作用，因此，在正常生理(如青春期和妊娠)以及各种代谢和免疫疾病中，免疫细胞也经历了类似的变化。两者之间这种密切关系的一个重要组成部分是性别差异。许多自身免疫性疾病，如系统性红斑狼疮和多发性硬化症，在女性中的患病率显著增加，而相比之下，埃博拉和中东呼吸综合征等传染病影响的男性比女性更多。因此，代谢动态平衡和免疫功能的基本方面在男性和女性中受到不同的调节。这可以在性激素-免疫相互作用中观察到，在这种相互作用中，雄激素，如睾酮，已经显示出免疫抑制作用，而雌激素则处于光谱的相反一侧，具有促进免疫的机制。此外，两性在代谢调节方面表现出显著的差异，雌性的发情周期会导致性状的变异，而雄性则表现出更明显的代谢性疾病表型。很可能这些差异既是代谢性和自身免疫性疾病发展的基础，也是对当前治疗方案的反应的基础。免疫代谢中的性别二态现象已经成为一个热门的研究领域，旨在揭示不同代谢组织和免疫细胞类型中的性别偏见效应分子，识别常见效应分子的性别偏见细胞类型特异性功能，并了解自身免疫发病过程中代谢和免疫功能的性别差异是否相互影响。在这篇综述中，我们将总结最近的发现，这些发现解决了免疫代谢中性二型性的关键问题，以及它们对自身免疫性疾病临床治疗的翻译意义。
Immune cells play essential roles in metabolic homeostasis and thus, undergo analogous changes in normal physiology (e.g., puberty and pregnancy) and in various metabolic and immune diseases. An essential component of this close relationship between the two is sex differences. Many autoimmune diseases, such as systemic lupus erythematous and multiple sclerosis, feature strikingly increased prevalence in females, whereas in contrast, infectious diseases, such as Ebola and Middle East Respiratory Syndrome, affect more men than women. Therefore, there are fundamental aspects of metabolic homeostasis and immune functions that are regulated differently in males and females. This can be observed in sex hormone-immune interaction where androgens, such as testosterone, have shown immunosuppressive effects whilst estrogen is on the opposite side of the spectrum with immunoenhancing facilitation of mechanisms. In addition, the two sexes exhibit significant differences in metabolic regulation, with estrous cycles in females known to induce variability in traits and more pronounced metabolic disease phenotype exhibited by males. It is likely that these differences underlie both the development of metabolic and autoimmune diseases and the response to current treatment options. Sexual dimorphism in immunometabolism has emerged to become an area of intense research, aiming to uncover sex-biased effector molecules in the various metabolic tissues and immune cell types, identify sex-biased cell-type-specific functions of common effector molecules, and understand whether the sex differences in metabolic and immune functions influence each other during autoimmune pathogenesis. In this review, we will summarize recent findings that address these critical questions of sexual dimorphism in immunometabolism as well as their translational implications for the clinical management of autoimmune diseases.
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影响因子：
5.1
作者：
Billi AC;Kahlenberg JM;Gudjonsson JE
通讯作者：
Gudjonsson JE
影响因子：
3.7
作者：
Gomez A;Luckey D;Yeoman CJ;Marietta EV;Berg Miller ME;Murray JA;White BA;Taneja V
通讯作者：
Taneja V
影响因子：
2.6
作者：
Christou EAA;Banos A;Kosmara D;Bertsias GK;Boumpas DT
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Boumpas DT
影响因子：
4.2
作者：
Golden LC;Voskuhl R
通讯作者：
Voskuhl R
影响因子：
7.3
作者：
Edwards M;Dai R;Ahmed SA
通讯作者：
Ahmed SA