Prolonged plasma glucose elevation on oral glucose tolerance test in young healthy Japanese individuals
Prolonged plasma glucose elevation on oral glucose tolerance test in young healthy Japanese individuals
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DOI：
10.1002/edm2.98
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发表时间：
2020-01-01
期刊：
影响因子：
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通讯作者：
Murakami, Masami
中科院分区：
文献类型：
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作者：
Ishigaki, Hirotaka;Yoshida, Akihiro;Murakami, Masami
目的：本研究旨在通过口服葡萄糖耐量试验（OGTT）评估日本年轻人的胰岛素分泌和抵抗。研究对象和方法：我们招募了595名年龄在22-29岁之间的年轻健康日本人。他们进行OGTT，根据他们的血浆葡萄糖浓度下降到空腹葡萄糖浓度以下的时间（分别为30、60或120分钟或从不作为组I、II、III和IV），将他们的结果分为4组（I-IV）。结果如下：我们将575名正常葡萄糖耐受受试者分为4组（I-IV），I组：28名（4.9%），II组：120名（20.9%），III组：143名（24.9%），IV组：284名（49.4%）。Matsuda、胰岛素生成和处置指数从组I至组IV降低。反映胰岛素分泌和敏感性组成的处置指数的ROC曲线将长期葡萄糖升高组（组III + IV）与快速葡萄糖降低组（组II; AUC = 0.847）分类。结论：即使在一个年轻和健康的日本人的生理范围内的血糖控制，有一个连续的胰岛素敏感性和分泌下降。
Aims: This study aims to assess insulin secretion and resistance through oral glucose tolerance test (OGTT) among young Japanese individuals. Subjects and methods: We enrolled 595 young healthy Japanese individuals aged 22-29 years. They underwent an OGTT, and their results were divided into 4 groups (I-IV), according to the time at which their plasma glucose concentration declined below the fasting glucose concentration (30, 60 or 120 minutes or never as groups I, II, III and IV, respectively). Results: We classified 575 normal glucose-tolerant subjects into 4 groups (I-IV) with I: 28 (4.9%), II: 120 (20.9%), III: 143 (24.9%) and IV: 284 (49.4%) individuals. The Matsuda, insulinogenic and disposition indices were decreased from groups I to IV. ROC curves of disposition index reflecting the composition of insulin secretion and sensitivity classified the prolonged glucose elevation group (group III + IV) from the rapid glucose lowering group (group II; AUC = 0.847). Conclusions: Even in a young and healthy Japanese individual within the physiological range of glycaemic control, there is a sequential decrease in insulin sensitivity and secretion.