Optimizing Process Parameters in Commercial Micro-Stereolithography for Forming Emulsions and Polymer Microparticles in Nonplanar Microfluidic Devices
Optimizing Process Parameters in Commercial Micro-Stereolithography for Forming Emulsions and Polymer Microparticles in Nonplanar Microfluidic Devices
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DOI：
10.1002/admt.201800408
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发表时间：
2019-01-01
影响因子：
6.8
通讯作者：
Thiele, Julian
中科院分区：
文献类型：
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作者：
Maennel, Maxi;Selzer, Lukas;Thiele, Julian
采用微立体光刻技术（mu SL）制备了具有非平面微通道设计的微流控器件，用于水包油（O/W）和油包水（W/O）单乳液以及油包水包油（O/W/O）和水包油包水（W/O/W）双乳液的形成。通过研究分离距离、印刷方向和X、Y平面中的体素补偿作为关键印刷参数，印刷了具有从500 μ m到75 μ m变化的通道横截面的微流池，其因此真正类似于由常规冲压微流体产生的那些。不需要控制微通道的润湿性，这些流动池用于形成O/W和W/O微滴，直径约为130-80 μ m，尺寸分布窄，为2%，频率高达2.9kHz。然后将所形成的乳液液滴分别用作制备疏水性和亲水性聚合物微粒的模板。同样，在单个微流池中制备0/W/0和W/0/W双重乳液，以扩展非平面3D打印微流体装置的适用性。对于每组实验，使用相同的单个流动池来证明3D打印流动池与通过传统的组合光刻和软光刻制造的微流体流动池相比的可重复使用性和鲁棒性。
The fabrication of microfluidic devices with nonplanar microchannel design by micro-stereolithography (mu SL) for oil-in-water (O/W) and water-in-oil (W/O) single emulsion as well as oil-in-water-in-oil (O/W/O) and water-in-oil-in-water (W/O/W) double emulsion formation is presented. By investigating separation distance, printing direction and voxel compensation in X,Y-plane as key printing parameters, microflow cells with channel cross-sections varying from 500 to 75 mu m are printed, which are thus truly similar to those yielded by conventional stamped microfluidics. Without the need of controlling microchannel wettability, these flow cells are employed for forming O/W and W/O microdroplets, approximate to 130-80 mu m in diameter and narrow size distribution of 2%, and at frequencies of up to 2.9 kHz. The as-formed emulsion droplets are then utilized as templates for preparing hydrophobic and hydrophilic polymer microparticles, respectively. Likewise, O/W/O and W/O/W double emulsions are prepared in a single microflow cell to extend the applicability of nonplanar, 3D-printed microfluidic devices. For each set of experiments, the same single flow cell is used to prove the reusability and robustness of the 3D-printed flow cells compared to microfluidic flow cells fabricated by conventional, combined photo- and soft-lithography.