Effect of L-histidine pretreatment on methamphetamine induced sterotyped behaviour in rats.
Effect of L-histidine pretreatment on methamphetamine induced sterotyped behaviour in rats.
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L-组氨酸预处理对甲基苯丙胺诱导的大鼠刻板行为的影响。
DOI：
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发表时间：
1979
影响因子：
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通讯作者：
A. Chandorkar
中科院分区：
文献类型：
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作者：
M. Muley;J. Balsara;A. Chandorkar
组胺前体L-组氨酸预处理可延迟甲基苯丙胺所致刻板行为的发生、缩短其持续时间和降低其强度，而H1受体阻断剂氯环利嗪不仅能增强甲基苯丙胺所致刻板行为，而且能阻断L-组氨酸对甲基苯丙胺刻板行为的抑制作用。我们的研究结果表明，中枢组胺能系统通过对纹状体多巴胺能系统的调节作用，可能影响锥体外系运动系统的功能。
Pretreatment with L-histidine precursor of histamine was found to delay the onset, shorten the duration and decrease the intensity of stereotyped behaviour induced by methamphetamine while chlorcylizine a H1 receptor blocker was found not only to potentiate methamphetamine induced sterotyped behaviour but also to block the inhibitory effect of L-histidine on methamphetamine stereotypy. Our results indicate that the central histaminergic system by exerting a modulatory influence on the striatal dopaminergic system may influence the functioning of the extrapyramidal motor system.