Design and synthesis of 1-(beta-D-ribofuranosyl)imidazo[4,5-c]pyrazoles as 5:5 bicyclic analogs of purine nucleosides.
Design and synthesis of 1-(beta-D-ribofuranosyl)imidazo[4,5-c]pyrazoles as 5:5 bicyclic analogs of purine nucleosides.
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设计和合成 1-(β-D-呋喃核糖基)咪唑并[4,5-c]吡唑作为嘌呤核苷的 5:5 双环类似物。
DOI：
10.1093/nass/nrn300
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
Townsend,LeroyB
中科院分区：
文献类型：
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作者：
Chien,Tun-Cheng;Drach,JohnC;Townsend,LeroyB
5-烷基氨基吡唑核苷经亚硝基化得到相应的N1-核糖基化5-烷基氨基-4-亚硝基吡唑。这些5-烷氨基-4-亚硝基吡唑在吡啶中于回流温度下进行分子内环化脱水反应，以高产率得到N-1核糖基二咪唑并[4，5-c]吡唑。
5-Alkylaminopyrazole nucleosides underwent nitro-sation to give the correspondingN1-ribosylated 5-alkyl-amino-4-nitrosopyrazoles. The intramolecular cyclo-dehydration reactions of these 5-alkylamino-4-nitroso-pyrazoles were carried out in pyridine at refluxtemperature to afford the ring-closureN-1ribosylatedimidazo[4,5-c]pyrazoles in good yields.