NEUROTRANSMITTER ALTERATIONS IN A MODEL OF PERINATAL HYPOXIC-ISCHEMIC BRAIN INJURY
NEUROTRANSMITTER ALTERATIONS IN A MODEL OF PERINATAL HYPOXIC-ISCHEMIC BRAIN INJURY
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DOI：
10.1002/ana.410130507
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发表时间：
1983-01-01
影响因子：
11.2
通讯作者：
JOHNSTON, MV
中科院分区：
文献类型：
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作者：
JOHNSTON, MV
在未成熟大鼠纹状体中检测神经递质特异性神经元对缺氧缺血的脆弱性。颈动脉结扎加2小时的8%O2气氛在1周龄产生同侧纹状体损伤，并减少半球质量2和6周后。纹状体损伤总是比上覆皮层的损伤更严重。超过一半的动物有大理石状状态，这是一种在足月人类婴儿缺氧缺血性损伤后在基底神经节和丘脑中观察到的神经病理学变化。损伤后2周，胆碱能、多巴胺能和GABA能神经元的标记物均减少，但胆碱能标记物的减少大于其他2种递质。毒蕈碱胆碱能受体相对保存，但其分布被打乱。在成年动物中，胆碱能神经元标记物的特定活性是正常的，这表明神经递质的平衡在早期损伤后恢复。
Vulnerability of neurotransmitter-specific neurons to hypoxia-ischemia was examined in the immature rat corpus striatum. Carotid artery ligation plus 2 h of 8% O2 atmosphere at 1 wk of age produced ipsilateral striatal injury, and reduced hemisphere mass 2 and 6 wk later. Striatal injury was always more severe than damage to overlying cortex. Over half the animals had status marmoratus, a neuropathological change seen in the basal ganglia and thalamus after hypoxic-ischemic injury in full-term human infants. Two weeks after the insult, markers for cholinergic, dopaminergic and GABA-containing neurons were all reduced, but the reduction in cholinergic markers was greater than that for the other 2 transmitters. Muscarinic cholinergic receptors were relatively preserved, but their distribution was disrupted. In adult animals specific activity of cholinergic neuronal markers was normal, suggesting that the balance of neurotransmitters was restored after the early insult.