A central role of Arabidopsis thaliana ovate family proteins in networking and subcellular localization of 3-aa loop extension homeodomain proteins
A central role of Arabidopsis thaliana ovate family proteins in networking and subcellular localization of 3-aa loop extension homeodomain proteins
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DOI：
10.1073/pnas.0501181102
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发表时间：
2005-03-29
影响因子：
11.1
通讯作者：
Uhrig, JF
中科院分区：
文献类型：
--
作者：
Hackbusch, J;Richter, K;Uhrig, JF
活细胞的组织是基于相互作用的分子网络。3-aa环延伸（TALE）同源结构域蛋白，植物分生组织功能和叶片发育的基本调节剂的蛋白质相互作用的系统分析，揭示了一个高度连接的，复杂的网络。该网络包括拟南芥卵形家族蛋白（AtOFPs）的9个成员，AtOFPs是一种植物特异性蛋白家族，表明与TALE同源结构域蛋白有密切的功能联系。证据表明，AtOFP 1是一个重要的多效性发育调节。AtOFP 1和AtOFP 5与细胞骨架相关，并调节TALE同源结构域蛋白的亚细胞定位，这表明植物发育中以前未被认识到的控制机制。
The organization of living cells is based on networks of interacting molecules. Systematic analysis of protein interactions of 3-aa loop extension (TALE) homeodomain proteins, fundamental regulators of plant meristem function and leaf development, revealed a highly connected, complex network. The network includes nine members of Arabidopsis thaliana ovate family proteins (AtOFPs), a plant-specific protein family, indicating a close functional connection to TALE homeodomain proteins. Evidence is provided that AtOFP1 is an essential pleiotropic developmental regulator. AtOFP1 and AtOFP5 are shown to associate with the cytoskeleton and to regulate subcellular localization of TALE homeodomain proteins, suggesting a previously unrecognized control mechanism in plant development.