Asymptomatic Plasmodium spp. infection in Tierralta, Colombia
Asymptomatic Plasmodium spp. infection in Tierralta, Colombia
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DOI：
10.1590/s0074-02762008000700007
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发表时间：
2008-11-01
期刊：
影响因子：
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通讯作者：
Nicholls, Rubén Santiago
中科院分区：
文献类型：
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作者：
Cucunubá, Zulma Milena;Guerra, Ángela Patricia;Nicholls, Rubén Santiago
目的是确定无症状疟原虫的患病率。在哥伦比亚科尔多瓦蒂尔拉尔塔的努埃沃泰村，通过厚涂片和PCR检测的感染及其与人口统计学和流行病学特征的关系，采用随机概率抽样进行了一项横断面人群研究。在第0天从212人中采集静脉血样品用于厚涂片和PCR。在第14天和第28天进行临床随访和厚涂片。疟原虫的流行。感染率为17.9%（38/212; 95%CI：12.5-23.3%），无症状疟原虫的患病率为17.9%。感染率为14.6%（31/212; 95% CI：9.6-19.6%）。间日疟原虫感染率（20/31; 64.5%）高于恶性疟原虫感染率（9/31; 29%）和混合感染率（2/31; 6.5%）。男性无症状感染者的患病率（19.30%）显著高于女性（9.18%）（患病率比：2.10; 95%CI：1.01-4.34%; p = 0.02）。出现症状的人在第0天的寄生虫血症显著高于无症状的人，分别为1，881.5 +/-3，759和79 +/- 106.9（p = 0.008）。PCR检测到的感染比厚涂片多50%。无症状疟原虫的存在。感染突出了在居住在流行地区的无症状人群中进行积极搜索的重要性。
With the aim of determining the prevalence of asymptomatic Plasmodium spp. infection by thick smear and PCR and its association with demographic and epidemiological characteristics in the village of Nuevo Tay, Tierralta, Cordoba, Colombia, a cross-sectional population study was carried out, using random probabilistic sampling. Venous blood samples were taken from 212 people on day 0 for thick smear and PCR. Clinical follow-up and thick smears were carried out on days 14 and 28. The prevalence of Plasmodium spp. infection was 17.9% (38/212; 95% CI: 12.5-23.3%) and the prevalence of asymptomatic Plasmodium spp. infection was 14.6% (31/212; 95% CI: 9.6-19.6%). Plasmodium vivax was found more frequently (20/31; 64.5%) than Plasmodium falciparum (9/31; 29%) and mixed infections (2/31; 6.5%). A significantly higher prevalence of asymptomatic infection was found in men (19.30%) than in women (9.18%) (prevalence ratio: 2.10; 95% CI: 1.01-4.34%; p = 0.02). People who developed symptoms had a significantly higher parasitemia on day 0 than those who remained asymptomatic, of 1,881.5 +/- 3,759 versus 79 +/- 106.9 (p = 0.008). PCR detected 50% more infections than the thick smears. The presence of asymptomatic Plasmodium spp. infection highlights the importance of carrying out active searches amongst asymptomatic populations residing in endemic areas.