Neural substrates of emotion as revealed by functional magnetic resonance imaging.
Neural substrates of emotion as revealed by functional magnetic resonance imaging.
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DOI：
10.1097/00146965-200403000-00002
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发表时间：
2004-03-01
期刊：
影响因子：
--
通讯作者：
Lavin, Thomas B
中科院分区：
文献类型：
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作者：
Lee, Gregory P;Meador, Kimford J;Lavin, Thomas B
目的：目的：研究情绪体验的脑回路，确定大脑半球是否专门负责积极和消极的情绪体验。背景：最近的研究已经提供了一个初步的草图，情绪处理的神经基础，涉及边缘系统和皮质脑区的专门贡献。电生理学、功能成像和Wada测试数据表明，积极的、接近相关的情绪与左大脑半球区域相关，而消极的、退缩相关的情绪似乎与右大脑半球机制更一致。这些情绪-在10名健康对照者中使用功能磁共振成像研究了神经关联，其中20张阳性和20张阴性图片来自国际情感图片系统在一个平衡的顺序。图片被认为是在1.5 Telsa扫描仪通过计算机化的视频goggles.Results：情绪化的图片导致双侧内侧额叶/前扣带回，背外侧额叶，杏仁核/前颞区，小脑血流量显着增加。负面情绪图片导致右脑更大的激活，而正面情绪图片导致左脑更大的激活。结果与强调连接皮质下结构与内侧颞叶、前扣带、情绪的效价模型假定大脑的偏侧化专门化为积极和消极的情绪体验.
OBJECTIVES: To examine the brain circuitry involved in emotional experience and determine whether the cerebral hemispheres are specialized for positive and negative emotional experience.BACKGROUND: Recent research has provided a preliminary sketch of the neurologic underpinnings of emotional processing involving specialized contributions of limbic and cortical brain regions. Electrophysiologic, functional imaging, and Wada test data have suggested positive, approach-related emotions are associated with left cerebral hemisphere regions, whereas negative, withdrawal-related emotions appear to be more aligned with right hemisphere mechanisms.METHOD: These emotional-neural associations were investigated using functional magnetic resonance imaging in 10 healthy controls with 20 positively and 20 negatively valenced pictures from the International Affective Picture System in a counterbalanced order. Pictures were viewed within a 1.5 Telsa scanner through computerized video goggles.RESULTS: Emotional pictures resulted in significantly increased blood flow bilaterally in the mesial frontal lobe/anterior cingulate gyrus, dorsolateral frontal lobe, amygdala/anterior temporal regions, and cerebellum. Negative emotional pictures resulted in greater activation of the right hemisphere, and positive pictures caused greater activation of the left hemisphere.CONCLUSIONS: Results are consistent with theories emphasizing the importance of circuitry linking subcortical structures with mesial temporal, anterior cingulate, and frontal lobe regions in emotion and with the valence model of emotion that posits lateralized cerebral specialization for positive and negative emotional experience.