Both environmental tobacco smoke and personal smoking is related to asthma and wheeze in teenagers
Both environmental tobacco smoke and personal smoking is related to asthma and wheeze in teenagers
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DOI：
10.1136/thx.2010.143800
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发表时间：
2011-01-01
期刊：
影响因子：
10
通讯作者：
Ronmark, Eva
中科院分区：
文献类型：
--
作者：
Hedman, Linnea;Bjerg, Anders;Ronmark, Eva
背景环境烟草烟雾(ETS)已被报道为儿童哮喘的重要危险因素。在成年人中，个人吸烟是呼吸道症状和疾病的主要原因。这些暴露对青少年哮喘和哮喘患病率的影响还不是很清楚。目的研究ETS和个人吸烟对青少年哮喘和哮喘患病率的独立和联合影响。方法瑞典北部自1996年以来一直在进行一项关于学龄儿童哮喘和过敏性疾病的纵向研究。邀请了三个城市的所有7-8岁儿童，3430名参与者(97%)接受了年度问卷调查。在16-17岁，82%的初始参与者参与了2005年的调查。结果接触母体ETS的人群和日常吸烟者中，医生诊断的哮喘、曾经喘息和现在喘息的患病率显著高于其他人群。在多变量分析中，母亲的ETS是医生诊断的哮喘和曾经喘息的重要危险因素(OR 1.3-1.5)，以及个人每天吸烟导致当前喘息(OR 2.0)。在每天吸烟者中，哮喘和喘息的OR值最高，这些吸烟者也暴露在母亲的ETS中，OR值分别为1.7和2.5。结论ETS和个人吸烟均与青少年哮喘和喘息密切相关。母亲接触ETS与终生症状有关，但青少年每天吸烟与当前症状的相关性更强。
Background Environmental tobacco smoke (ETS) has been reported as a significant risk factor for childhood asthma. Among adults, personal smoking is a major cause of respiratory symptoms and diseases. The effects of these exposures on the prevalence of asthma and wheeze among teenagers are less well known.Objective The aim was to study the independent and combined effects of ETS and personal smoking on the prevalence of asthma and wheeze in teenagers.Methods A longitudinal study of asthma and allergic diseases in schoolchildren has been in progress in Northern Sweden since 1996. All children aged 7-8 years in three municipalities were invited and 3430 (97%) participants have been followed by annual questionnaires. At the age 16-17 years, 82% of the initial participants took part in the 2005 survey.Results Prevalence of physician-diagnosed asthma, ever wheeze and current wheeze was significantly higher among those exposed to maternal ETS and among daily smokers. In multivariate analyses, maternal ETS was a significant risk factor for physician-diagnosed asthma and ever wheeze (OR 1.3-1.5) and personal daily smoking for current wheeze (OR 2.0). ORs for asthma and ever wheeze were highest among daily smokers who were also exposed to maternal ETS with ORs of 1.7 and 2.5, respectively. A significant dose-response association between number of cigarettes/day and the prevalence of wheeze was also found.Conclusions Both ETS and personal smoking were significantly related to asthma and wheeze in teenagers. Maternal ETS exposure was associated with lifetime symptoms, but daily smoking among the teenagers was more strongly related to current symptoms.