Improving the Performances of a "Brick Mass Spectrometer" by Quadrupole Enhanced Dipolar Resonance Ejection from the Linear Ion Trap
Improving the Performances of a "Brick Mass Spectrometer" by Quadrupole Enhanced Dipolar Resonance Ejection from the Linear Ion Trap
复制标题
通过线性离子阱四极增强偶极共振弹射提高“砖式质谱仪”的性能
DOI：
10.1021/acs.analchem.8b03332
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发表时间：
2018-10-02
影响因子：
7.4
通讯作者：
Xu, Wei
中科院分区：
文献类型：
--
作者：
Jiang, Ting;Xu, Qian;Xu, Wei
以前，我们实验室开发了一种由正弦频率扫描技术驱动的微型质谱仪，称为Brick质谱仪（Jiang et al. Anal. 2017，89，5578）。频率扫描技术能够实现小型化的电子设备和更宽的质量范围，但由于与传统的电压扫描技术相比相对较低的工作射频（rf）电压，它也受限于质量分辨率和灵敏度的降低。为了提高Brick质谱计的性能，提出了一种四极增强偶极共振喷射（QE-偶极共振喷射）方法。优化后的Brick质谱计的质量分辨率和灵敏度可提高2倍以上，离子阱内的空间电荷效应也可降低。此外，这种QE-偶极共振喷射方法在高压下是有效的，这将潜在地允许我们通过在更高的压力下操作来进一步简化Brick质谱仪。该方法也适用于以频率扫描模式或电压扫描模式操作的任何离子阱，以及在小型化仪器或台式仪器中操作的任何离子阱。
Previously, a miniature mass spectrometer driven by a sinusoidal frequency scanning technique, named as Brick mass spectrometer, was developed in our lab (Jiang et al. Anal. Chem. 2017, 89, 5578). The frequency scanning technique enabled miniaturized electronics and broader mass range, but it was also limited in reduced mass resolution and sensitivity due to a relatively low operating radio frequency (rf) voltage in comparison with the conventional voltage scanning technique. To improve performances of the Brick mass spectrometer, a quadrupole enhanced dipolar resonance ejection (QE-dipolar resonance ejection) method was proposed in this work. After optimization, mass resolution and sensitivity of the Brick mass spectrometer could be improved by no less than 2 times, and space charge effects within the ion trap could also be reduced. Furthermore, this QE-dipolar resonance ejection method is effective at elevated pressures, which would potentially allow us to further miniaturize the Brick mass spectrometer by operating it at higher pressures. This method is also applicable to any ion trap operated in either frequency scanning mode or voltage scanning mode and operated in either miniaturized instruments or benchtop instruments.