Approach to recurrent fever in childhood.
Approach to recurrent fever in childhood.
复制标题
儿童反复发烧的治疗方法。
DOI：
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复制
发表时间：
2017
期刊：
影响因子：
--
通讯作者：
R. Laxer
中科院分区：
文献类型：
--
作者：
G. Soon;R. Laxer
目的
提供一种儿童反复发热的方法，解释何时可以排除感染、恶性肿瘤和免疫缺陷，并描述周期性发热和其他自身炎症综合征的特征。
信息来源
检索PubMed中关于周期性发热和自身炎症综合征的发病机制、临床表现、诊断、预后和治疗的相关文章。
主要信息
发烧是儿童疾病的常见症状，最常见的原因是感染。然而，当急性和慢性感染已被排除，当发热模式成为复发性或周期性，自身炎症性疾病，包括周期性发热综合征，应考虑扩大频谱。家族性地中海热是最常见的遗传性单基因自身炎症综合征，早期识别和治疗可以预防其危及生命的并发症，系统性淀粉样变性。周期性发热、口疮性口炎、咽炎和腺炎综合征是儿童期最常见的周期性发热综合征;然而，其潜在的遗传基础仍然未知。
结论
周期性发热综合征和其他自身炎症性疾病在儿童和成人中越来越多地被认识到，特别是作为反复发热的原因。个别情况下，他们是罕见的，但全面的病史和体格检查可以导致他们的早期识别，诊断和适当的治疗。
OBJECTIVE
To provide an approach to recurrent fever in childhood, explain when infections, malignancies, and immunodeficiencies can be excluded, and describe the features of periodic fever and other autoinflammatory syndromes.
SOURCES OF INFORMATION
PubMed was searched for relevant articles regarding the pathogenesis, clinical findings, diagnosis, prognosis, and treatment of periodic fever and autoinflammatory syndromes.
MAIN MESSAGE
Fever is a common sign of illness in children and is most frequently due to infection. However, when acute and chronic infections have been excluded and when the fever pattern becomes recurrent or periodic, the expanding spectrum of autoinflammatory diseases, including periodic fever syndromes, should be considered. Familial Mediterranean fever is the most common inherited monogenic autoinflammatory syndrome, and early recognition and treatment can prevent its life-threatening complication, systemic amyloidosis. Periodic fever, aphthous stomatitis, pharyngitis, and adenitis syndrome is the most common periodic fever syndrome in childhood; however, its underlying genetic basis remains unknown.
CONCLUSION
Periodic fever syndromes and other autoinflammatory diseases are increasingly recognized in children and adults, especially as causes of recurrent fevers. Individually they are rare, but a thorough history and physical examination can lead to their early recognition, diagnosis, and appropriate treatment.
DOI：
10.1056/nejmoa0807865
发表时间：
2009-06-04
期刊：
The New England journal of medicine
影响因子：
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作者：
Aksentijevich I;Masters SL;Ferguson PJ;Dancey P;Frenkel J;van Royen-Kerkhoff A;Laxer R;Tedgård U;Cowen EW;Pham TH;Booty M;Estes JD;Sandler NG;Plass N;Stone DL;Turner ML;Hill S;Butman JA;Schneider R;Babyn P;El-Shanti HI;Pope E;Barron K;Bing X;Laurence A;Lee CC;Chapelle D;Clarke GI;Ohson K;Nicholson M;Gadina M;Yang B;Korman BD;Gregersen PK;van Hagen PM;Hak AE;Huizing M;Rahman P;Douek DC;Remmers EF;Kastner DL;Goldbach-Mansky R
通讯作者：
Goldbach-Mansky R